Structure of PDB 5tcu Chain S1 Binding Site BS01

Receptor Information

>5tcu Chain S1 (length=80) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325)

IRIRLKAYDHRVIDQSAEKIVETAKRSGADVSGPIPLPTEKSVYTIIRAV
HKYKDSREQFEQRTHKRLIDIVNPTPKTVD

Ligand information

>5tcu Chain A (length=1464)

auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaaua
caugcaagucgagcgaacguuagcggcggacgggugaguaacacguggau
aaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccgg
auaauauagugaaagacacuuauagauggauccgcgcugcauuagcuagu
ugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagg
gugaucggccacacuggaacugagacacgguccagacuccuacgggaggc
agcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccg
cgugagugaugaaggucuucggaucguaaaacucuguuauuagggagaac
auaugugcacaucuugacguaccuaaucagaaagccacggcuaacuacgu
gccagcagccgcgguaauacguagguggcaagcguuauccggaauuauug
ggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacg
gcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagag
gaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaa
caccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcga
aagcguggggaucaaacaggauuagauacccugguaguccacgccguaaa
cgaugagugcuaaguguuagggggugccccuuagugcugcagcuaacgca
uuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaa
uugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaa
cgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauag
agccuuccccuucgggggacaaagugacagguggugcaugguugucguca
gcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuua
agcuuaguugccaucauuaaguugggcacucuaaguugacugccggugac
aaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauu
ugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcg
aggucaagcaaucccauaaaguuguucucaguucggauuguagucugcaa
cucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuac
ggugaauacguucccgggucuuguacacaccgcccgucacaccacgagag
uuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucga
aggugggacaaaugauuggggugaagucguaacaagguagccguaucgga
aggugcggcuggau

.....<<<<..[.(((..>>>>.<<<<.<<<<<...<<<<<<<.....<<
<.<<<...<<..<<........>>>>.......<<........<<<<<<<
..<<...<<<<<<<.<<.<<....<<.<<<....>>>.>>......>>>>
..................>>>>>>>..>>>>>>>>>.<<<....<<<...
<<<<<<<.......>>>>>>>.>>>......>>>..<<<.<<<<....>>
>>....>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>..
.>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>
...<<<<.......<<<....>>>......>>>>................
..<<<<..>>>>.....................<<<<<.((...<<<<<.
....<<.)).>>.......>>>>>>>>>>..>>>>>>>>>..........
<<<((.....<<<.<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<
<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<.<..<
<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...
........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>.>>>..
..<<<<<<<...<...<<<<.........>>>>...>>>>>>>>......
....<<<<<<..<<<<<<<<<<<<..>>>>>>>>>>>>...<<..))>>.
....>>>>>>.>>>.<<<......<<<<....>>>>....>>>...))).
]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......
..>>..........<<<<<<<......<<<.<<.....<<<<<....>>>
>>...<<<<.....>>.>>.>>.>.>>.<<<.<<<..<<<<<<.......
<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.
.<.<..............................>>.......<<<<...
..>>>>.........>>>>.........>>>...>>>>>>>>>...>>>>
>>>...>>.>>>>>>>>.....<<<<..<.....<<<..<<...<<<...
.>>>...>>...>>>.....>..>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<
<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>..
.>>>.>.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5tcu Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): R9 H15 G38 P39 I40 L42 P43 T44 T50 R53 V55 H56 K57 Y58
• Binding residue (residue number reindexed from 1): R4 H10 G33 P34 I35 L37 P38 T39 T45 R48 V50 H51 K52 Y53

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:5tcu, PDBe:5tcu, PDBj:5tcu
• PDBsum: 5tcu
• PubMed: 28487427
• UniProt: Q2YYP5|RS10_STAAB Small ribosomal subunit protein uS10 (Gene Name=rpsJ)