Structure of PDB 8uua Chain S Binding Site BS01

Receptor Information
>8uua Chain S (length=116) Species: 1642 (Listeria innocua) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRVKGGTVTRKRRKKIVKLAKGYYGSKHLLFKVANQAVMKSYQYAYRDRR
QKKRDFRRLWIARINAAARMQDLSYSKLMHGLKLAGIDINRKMLADLAVN
DIASFNTLADSAKKAL
Ligand information
>8uua Chain A (length=2894) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaag
aaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguug
auccagagauuuccgaaugggggaacccacuaucuuuagucggauaguau
ccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaaca
ucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggc
gagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguugua
ggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucugg
aaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccu
ccagaguggauccugaguacgacggaacacgugaaauuccgucggaaucc
gggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaac
caguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacag
uuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugaua
gcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguua
agcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaa
guaacaggucguagacccgaaaccaggugaucuacccauguccaggauga
agguaagguaauacuuacuggagguccgaacccacgcacguugaaaagug
cggggaugagguguggguagcggagaaauuccaaucgaacuuggagauag
cugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucau
ggagguagagcacuguuuggacuagcgaauucagauaaacuccgaaugcc
auguacuuauacucgggagucagacugcgagugauaagauccguagucga
aagggaaacagcccagaccaccaguuaagguccccaaauauauguuaagu
ggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagca
gccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgc
cgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccuag
guucgugguaggagagcguucuaagggcggugaagucagaccggaaggac
ugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaaggg
ugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucgucc
gcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgaugg
acaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggu
gacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagu
gagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugaug
gggaagcggaaguuccugauuucacgcugucaagaaaagccucuaggaag
aguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauc
cuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccg
uaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccg
cagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaa
accguaaggugacguauaggggcugacgccugcccggugcuggaagguua
agaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacg
gcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaa
guuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgaga
gacucggugaaauuauaguaccugugaagaugcagguuacccgcgacagg
acggaaagaccccguggagcuuuacugcaaccugauauggaauguuugua
ccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauac
gaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccg
ccacgcuaagcgcguggggagacagugucaggugggcaguuugacugggg
cggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaaug
gauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgag
acugacaagucgagcagggacgaaagucgggcuuagugauccggugguuc
cgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaaca
ggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucga
ugucggcucgucgcauccuggggcuguagucggucccaaggguugggcug
uucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacag
uucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuu
aguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgc
caggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagca
ucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaag
uaagaucccugaaagaugaucagguagauagguuuggaguggaaguguag
cgauacauggagcggacaaauacuaaucgaucgaggacuuaacc
<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<....
..<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....
>>......>>>>>.>.........<<....>>..<<<<<......<<...
..>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<
<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<...
...>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>
>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......
<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]..........
.....<<....>>....]].........<<<<....>>>>..........
...}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>
>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<..
.<<.......>>...>>>...<<....>>..<<<<.....>>>>......
>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<...
.<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>
>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......
>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<
<<.....<<<...<<<<<<<<........>>>>>>>>..>>.>.....>>
>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>..
..<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<.....
......<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>
>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>
>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>
>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>
>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<
.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>
.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>
...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<
...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<
..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>
>...........>>>>>...>>>...>>>>........>>>>>..>>..>
>.>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>
>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.
....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<.....
<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<.
.<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>
>><<<<<<.......>>>>>>........<...........<<<<<<...
..>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>
>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.((
(.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<.<<<<<
<.<<<.<.........<<<<<..<<<.......<<<<<<<....>>>>>>
>....>>>............>>>>>>.>>>.>>>>>>.>>>>>....<<.
<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<....
.>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<
<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<
<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.(
(..>>>>..))>>>>>>>.............>>>>..]]>>>>.......
<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.....
..<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<..
...>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>
>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.
..............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)
))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<.......
....>>>>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>.
...<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<.
...>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uua Mechanistic insights into the alternative ribosome recycling by HflXr.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		P2 R3 V4 K5 T8 T10 R11 R13 R14 K15 K22 G23 Y24 Y25 G26 S27 H29 L31 K33 N36 Q37 K41 S42 Y45 Y47 R48 D49 R50 R51 K53 K54 R55 F57 R58 R59 I62 N66 R70 S75 Y76 S77 H81 N91 R92 K93
Binding residue
(residue number reindexed from 1)		P1 R2 V3 K4 T7 T9 R10 R12 R13 K14 K21 G22 Y23 Y24 G25 S26 H28 L30 K32 N35 Q36 K40 S41 Y44 Y46 R47 D48 R49 R50 K52 K53 R54 F56 R57 R58 I61 N65 R69 S74 Y75 S76 H80 N90 R91 K92
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8uua, PDBe:8uua, PDBj:8uua
PDBsum8uua
PubMed38407413
UniProtA0A660JH71

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