Structure of PDB 8uu8 Chain S Binding Site BS01

Receptor Information
>8uu8 Chain S (length=118) Species: 1642 (Listeria innocua) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRVKGGTVTRKRRKKIVKLAKGYYGSKHLLFKVANQAVMKSYQYAYRDRR
QKKRDFRRLWIARINAAARMQDLSYSKLMHGLKLAGIDINRKMLADLAVN
DIASFNTLADSAKKALAK
Ligand information
>8uu8 Chain A (length=2901) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaag
aaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguug
auccagagauuuccgaaugggggaacccacuaucuuuagucggauaguau
ccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaaca
ucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggc
gagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguugua
ggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucugg
aaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccu
ccagaguggauccugaguacgacggaacacgugaaauuccgucggaaucc
gggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaac
caguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacag
uuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugaua
gcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguua
agcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaa
guaacaggucguagacccgaaaccaggugaucuacccauguccaggauga
agguaagguaauacuuacuggagguccgaacccacgcacguugaaaagug
cggggaugagguguggguagcggagaaauuccaaucgaacuuggagauag
cugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucau
ggagguagagcacuguuuggacuaggguaccgaauucagauaaacuccga
augccauguacuuauacucgggagucagacugcgagugauaagauccgua
gucgaaagggaaacagcccagaccaccaguuaagguccccaaauauaugu
uaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuag
aagcagccaccauugaaagagugcguaauagcucacuggucgagugaccc
cgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaa
ccuagguucgugguaggagagcguucuaagggcggugaagucagaccgga
aggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaag
aagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcu
cguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggc
gauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgau
ggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaa
gcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcug
ugauggggaaguacggaaguuccugauuucacgcugucaagaaaagccuc
uaggaagaguaguacugcccguaccgcaaaccgacacagguagaugagga
gagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaau
gaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgag
agagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucu
cugcaaaaccguaaggugacguauaggggcugacgccugcccggugcugg
aagguuaagaggagugcuuagcuucggcgaagguacgaauugaagcccca
guaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugu
cggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucuc
aacgagagacucggugaaauuauaguaccugugaagaugcagguuacccg
cgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaau
guuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcu
agcauacgaggaggcaauggugggauacuacccuggcuguaugaccauuc
uaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuug
acuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccu
cagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuuga
cugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccg
gugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggg
gauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggc
accucgaugucggcucgucgcauccuggggcuguagucggucccaagggu
ugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgu
gagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagc
uguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguu
guuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcu
gaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuu
cggaaaguaagaucccugaaagaugaucagguagauagguuuggagugga
aguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaac
c
<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<....
..<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....
>>......>>>>>.>.........<<....>>..<<<<<......<<...
..>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<
<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<...
...>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>
>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......
<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]..........
.....<<....>>....]].........<<<<....>>>>..........
...}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>
>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<..
.<<.......>>...>>>...<<....>>..<<<<.....>>>>......
>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>
>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..
>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<
<<.....<<<...<<<<<<<<...<<...>>...>>>>>>>>..>>.>..
...>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>
>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<
...........<<..<<<<<<<<<<<......<<<<<.<<<..<<<<...
....>>>>..>>>.........<<......>>...>>>>>..>>>>>>>>
>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<
<<..>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<...
.>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<
<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<..
...>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>
...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...
<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..
<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>
>...>>.............>>>>>...>>>...>>>>........>>>>>
..>>..>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<
.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<....
.<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...
>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<
..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>
>>..>>>>><<<<<<.......>>>>>>........<...........<<
<<<.......>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.
>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<
<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<
<.<<<<<<.<<<...........<<<<<..<<<.......<<<<<<<...
.>>>>>>>....>>>............>>>>>..>>>.>>>>>>.>>>>>
....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<
<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<.
..<<<<<.<......>>>>>>.....<<.[.(((>>....>>>>>>>...
<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<
<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>
.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.
<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<..
..>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<
<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<
<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<
...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<..
..>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<...
.<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>>
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uu8 Mechanistic insights into the alternative ribosome recycling by HflXr.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		P2 R3 V4 K5 T8 R11 R13 R14 K15 K19 K22 G23 Y24 Y25 L31 K33 Q37 K41 Y45 Y47 R48 D49 R50 R51 K54 R55 F57 R58 R59 I62 N66 R70 Y76 S77 H81 K84 N91 R92 K93
Binding residue
(residue number reindexed from 1)		P1 R2 V3 K4 T7 R10 R12 R13 K14 K18 K21 G22 Y23 Y24 L30 K32 Q36 K40 Y44 Y46 R47 D48 R49 R50 K53 R54 F56 R57 R58 I61 N65 R69 Y75 S76 H80 K83 N90 R91 K92
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8uu8, PDBe:8uu8, PDBj:8uu8
PDBsum8uu8
PubMed38407413
UniProtA0A660JH71

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