Structure of PDB 8u7j Chain S Binding Site BS01

Receptor Information
>8u7j Chain S (length=187) Species: 418127 (Staphylococcus aureus subsp. aureus Mu3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAMKIGVLALQGAVREHIRHIELSGHEGIAVKKVEQLEEIEGLILPGGES
TTLRRLMNLYGFKEALQNSTLPMFGTCAGLIVLAQDIVGEEGYLNKLNIT
VQRNSFGRQVDSFETELDIKGIATDIEGVFIRAPHIEKVGQGVDILCKVN
EKIVAVQQGKYLGVSFNPELTDDYRVTDYFINHIVKK
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain8u7j Chain S Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8u7j Structure and dynamics of the staphylococcal pyridoxal 5-phosphate synthase complex reveal transient interactions at the enzyme interface.
Resolution3.02 Å
Binding residue
(original residue number in PDB)		G46 E47 S48 C75 I79 R101 N102 R130
Binding residue
(residue number reindexed from 1)		G48 E49 S50 C77 I81 R103 N104 R132
Annotation score5
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Biological Process
GO:0006541 glutamine metabolic process
GO:0006543 glutamine catabolic process
GO:0008614 pyridoxine metabolic process
GO:0042823 pyridoxal phosphate biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:1903600 glutaminase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8u7j, PDBe:8u7j, PDBj:8u7j
PDBsum8u7j
PubMed38782204
UniProtA7WYT2|PDXT_STAA1 Pyridoxal 5'-phosphate synthase subunit PdxT (Gene Name=pdxT)

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