Structure of PDB 8oeq Chain S Binding Site BS01 |
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| >8oeq Chain B (length=1712)
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uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguacuacuuggauaaccgugguaa
uucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguau
uuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaa
cuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucug
cccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggg
uaacggggaauaaggguucgauuccggagagggagccugagaaacggcua
ccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacgg
ggagguagugacaauaaauaacgauacaggguuguaauuggaaugaguac
aauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguua
aaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagc
cgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggac
guuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucggggguaucaguauucaguugucagaggugaaauucuuggauu
uacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacg
caaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguau
ggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggag
uggagccugcggcuuaauuugacucaacacggggaaacucaccaggucca
gacacaauaaggauugacagauugagagcucuuucuugauuuugugggug
guggugcauggccguucuuaguugguggagugauuugucugcuuaauugc
gauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcug
guauagucacuucuuagagggacuaucgauuucaagucgauggaaguuug
aggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcg
cuacacugacggagccagcgaguauaagccuuggccgagaggucugggaa
aucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcuc
uucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuac
gucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcu
uagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuug
gucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccug
cggaaggaucau |
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
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......<<<..<<..<<....<<<..........<<.....<..<<....
...>>..>......>>........<<<<<..<<....>>..>>>>><...
<<<<<<.......((((((.<<<....>>>..............>>>>>>
.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>
.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.
>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>
>..>>>..>....>.>.....<<<<...<...>...>>>>......<<..
<...........>..>>.........<<<<<((......<<<<.....<<
..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.
....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>
>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<...
....>..<<<....>>>....>>......>>.>>..>>>.........<<
<..<<<<<<<<......))))))...>>>>>>>>>>>.....>>....<<
<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>
.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>
>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......
<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<
<..<<<.<<<<<<......<<........>>..........<<<<<....
..<<<<<........<<.<<<........>>>.>>......>>>>>...<
<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>
>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>
>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>
>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>
>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>..
..>>.......>>>>>>>...........<<<<<<..........>>>>>
>..........>>>>>>....<<<<<<<<.......>>>>>>>>......
>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<
.<<<..<<<<..<...<<<<.........>>>>...>..>>>>..>>>.>
>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>
>>>>>....... |
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| PDB | 8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement |
| Resolution | 3.3 Å |
Binding residue
(original residue number in PDB) | Q7 T8 F9 K13 T14 V18 H20 L27 K29 G32 Q39 R65 K67 G70 G71 G72 H73 V74 S75 Q76 K113 V117 R121 R122 M123 E124 P125 K126 K127 F128 R131 R134 R136 F137 Q138 K139 S140 Y141 |
Binding residue
(residue number reindexed from 1) | Q6 T7 F8 K12 T13 V17 H19 L26 K28 G31 Q38 R64 K66 G69 G70 G71 H72 V73 S74 Q75 K112 V116 R120 R121 M122 E123 P124 K125 K126 F127 R130 R133 R135 F136 Q137 K138 S139 Y140 |
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