Structure of PDB 8imx Chain S Binding Site BS01

Receptor Information
>8imx Chain S (length=513) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQI
SGLNALQLRLMVPVTVVFTKLPFTVVHEREIPLKYKMKIKCRFQKAYRRA
LDVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVR
GAFNIIGRRIVQVAQAMSLTEDVLAAALADHLPEEKRRPLKSSLGYEITF
SLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLG
VNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPEL
AHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDSKTYNASVLPVRVEVD
MVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARS
VENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELAS
GHLASAFVASQEAVTSSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAV
PILLSLVKIFLET
Ligand information
>8imx Chain D (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GTTQLRATATTLILCCLLIILPCFILP
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8imx Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
Resolution2.85 Å
Binding residue
(original residue number in PDB)		Q517 F519 A520 L527 P528 V531
Binding residue
(residue number reindexed from 1)		Q486 F488 A489 L496 P497 V500
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006506 GPI anchor biosynthetic process
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0042765 GPI-anchor transamidase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8imx, PDBe:8imx, PDBj:8imx
PDBsum8imx
PubMed37684232
UniProtQ96S52|PIGS_HUMAN GPI transamidase component PIG-S (Gene Name=PIGS)

[Back to BioLiP]