Structure of PDB 8eth Chain S Binding Site BS01

Receptor Information

>8eth Chain S (length=161) Species: 4896 (Schizosaccharomyces pombe)

ALKEYQVVGRKVVPKLFRMRLFAPNESVAKSRYWYFLKMINKVKKATGEI
VAINEISEPKPLKAKVFGIWIRYDSRSGTHNMYKEFRDTTRVGAVEAMYA
DMAARHRARFRSIRILKVVEVEKKEDVRRNYVKQLLNPHLKFPLPHRRTK
KVFAPHRPSTF

Ligand information

>8eth Chain 1 (length=1303)

uugaccucaaaucagguaggacuacgcgcuaagcgcaggaaaagaaaaua
accaugauucccucaguaacgugaagcgggaaaagcucaaauuugaaauc
uggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuug
aguguagacgaucggucuaaguuccuuggaacaggacgucagagagggug
agaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaag
agucgaguugugcagcucuaaauggguggucaucuaaagcuaaauauugg
cgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuu
ugaaaagagaguuaaauaguacgugaaauugcugaaagcauuggaaauca
gucuuaccugggugagaucaguagucucucgagacuaugcacucugaacc
ugugguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagg
uggcuguuuauagcccuuguuguaauacguccacuggggacugaggacug
cggcuucgugccaaggaugcugacauaaugguuuucaauggcccguccac
ggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccau
ccgcgaggugggaacgcccuggcgugcaccaucagagcauagcuguuggg
acccgaaagauggugaaccaucuaguagcugguuccugccgaagagcaga
aacucagaucaguuuuaaaugagaguuucuagugggccauuacuggcgau
gcgggccgaacgugagguuaaggugccggaauguacgcuagaaagguguu
aguuaacuagcccugggcgcuuaagcguacuacccauaccucaccgucug
gguuagcuuugagaagcucagacgaguaggcaggcguggagguuugugac
gaagccuugggcgugagccugggucgaacagccucuagugcagaucuugg
uggaaguagcagcgaaaccacagccugggggccaggucgucgcaauggua
auucaacuuaguacggaaccguugauucagaucauugguagagcuaucau
cugccggauaacggcugagccagaauccgugccagagcgacgauauguau
aaaaauagaggucucuccuguaucguagaagaugggcgaugguugaugaa
acggaaguguuuuauugacuuguccaugaaauuccagaauccauugcaua
cgacuuuaauguggaacgggguauuguagauuaagccuuuguucccaaga
uuu

........................<<<<<<.>>>>>.>.........<<.
...>>..<<<<<......<<>>.....>>>>>..<<<..<<.......<<
.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<.
.<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<..
...))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>....
....<<<<<<..>>>>>>.....<<<<<..>>>>>..>>>..........
........................<<....>>...............<<<
<....>>>>.............................<<<<<<<<<<<<
.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>>..>>>
>..>>>..<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<....
..<...>......>>>>>>>>......>>>>>.>>>>>>>>>>.......
.<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<..>>
>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.......>>>>..
.>>>...<<<<..<<<<<..>>>>>...>>>>....>>>>>>.>>>>>>>
.<<.<...<<<<<<..>>>>>>......>.>>..<<<<<<.....<<<<<
<<<.....<<<.<<...>>>>>..>>>>>>.>>..<<<<....>>>>...
.<<<.>>>...<<<<<<<...<<<(((.....<<<<<<.<<..<<<.<<<
<<<..>>>>>>>>>.))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<............>>>>>>>>>....>>>>>>..<<<<<<<<.<<...
...<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>
><<.....<<.>>....>>....<<<<<...>>>>><<<<<<<..<<<<.
<.<<<<<......<>.....>>>>>.><<<<<...<<<<...>>>>..>>
>>>.<<<<....<<<<.>>>>....>>>>.>>>>..>>>>>>>.....<<
.......<<<<..>>>>....>>........<<<<<....<<<<<<<<<<
<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.......
......>.....<<<<<<<<<.<<<...>>>....>>>>.>>>>>...>>
>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8eth Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): N61 S64 E65 P66 K67 P68 R83 H87 K91 A107 A110 A111 R112 H113 R114 L143 N144 H153 P169 H170 P172 S173 T174
• Binding residue (residue number reindexed from 1): N54 S57 E58 P59 K60 P61 R76 H80 K84 A100 A103 A104 R105 H106 R107 L136 N137 H146 P155 H156 P158 S159 T160

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8eth, PDBe:8eth, PDBj:8eth
• PDBsum: 8eth
• PubMed: 36423630
• UniProt: P0CT68|RL20A_SCHPO Large ribosomal subunit protein eL20A (Gene Name=rpl2001)