Structure of PDB 8etc Chain S Binding Site BS01

Receptor Information

>8etc Chain S (length=168) Species: 4896 (Schizosaccharomyces pombe)

ALKEYQVVGRKVPTEHEPVPKLFRMRLFAPNESVAKSRYWYFLKMINKVK
KATGEIVAINEISEPKPLKAKVFGIWIRYDSRSGTHNMYKEFRDTTRVGA
VEAMYADMAARHRARFRSIRILKVVEVEKKEDVRRNYVKQLLNPHLKFPL
PHRRTKKVFAPHRPSTFY

Ligand information

>8etc Chain 1 (length=2140)

auuugaccucaaaucagguaggacuacgcgcugaacucaauaagcgcagg
aaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcuc
aaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaa
gaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacg
ucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaa
gcgcuuucgaagagucgaguuguuugcagcucuaaauggguggucaucua
aagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaa
gaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaa
agggaagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaag
aauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggg
gacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaa
uggcccgucuacacggaccaaggagucuagcaucuaugcgaguguuuggg
ugaugaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccu
ggcgugcaccaucgaccgacccggaaggguuugaguaagagcauagcugu
ugggacccgaaagauggugaacuaugccugaauagggugaagccagagga
aacucugguggaggcucguuuggguauaggggcgaaagacuaaucgaacc
aucuaguagcugguuccugccgaaggcagaaacucagaucaguuuuaugu
guaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgau
gcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucag
acaccagaaaagguguuaguucaucuagacagcaggacgguggccaugga
agucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacua
gcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucug
gguuagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcaaauauucaaaugagaacuuugaagacugaaguggggaaagguucca
ugugaacagcaguuggacauggguuagucgauccuaagagauagggaagc
uccguaugaaaaucgaaagggaauccgguuaauauuccggaaccagaagg
uggaacacggcaacguaaaugaaguuggagacgucggcgggagcccuggg
aagaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuaucc
ggagcuaggguaugguguuuggaagaguucagcgccucaugcugaauccg
gugcgcucucgacggccuugaaaauccaacggaaguuucacaucuggucg
uacucauaaccgcagcaggucuccaaggugagccucuaguugauagaaca
auguagauaagggaagucggcaaaaugggaaucgauucccacugucccua
ucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucag
cgggguggcuuguggcagccaagcgcgacguugcuggcucuuccuaucau
accgaagcagaauucgguaagcguuggacccacuaauagggagcuggguu
ccuacugaugaagugucgucgcaaugguaauucaacuuaguacgagagga
accguugauucagaucauugguauuugcggcugccugacaaggcaaugcc
gcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauc
cgugccagaaagcgacgauuguauaaaaauagaggucucuccuguaucgu
agaagaugggcgaugguugaugaaacggaaguguuuuauugacuugucca
ugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauug
uaagcagcugcugagauuaagccuuuguucccaagauuug

..........................<<<<<<..........>>>>>.>.
........<<....>>..<<<<<......<<.>>.....>>>>>..<<<.
.<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....
<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.(
(......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>
>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>.
.>>>..................................<<....>>....
...........<<<<....>>>>...........................
.......<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......
.<<<<<<<......<...>......>>>>>>>.......>>>>>.>>>>>
>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>
>>..<<<<....>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<
<.......>>>>>..>>>...<<....>>........<<<<..<<<<<..
>>>>>...>>>>..<<<<<<<<....>>>.>>>.>>....>>>>>>.>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<..
..>>>>>>>.....>>>.>>>>>>>>>...<<.......>>......>>>
>>>......>.>>..<<<<<<....<<<<<<<<<<...<<<.<<<<<<..
>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...
.<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<
..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.....
....>>....>>.........<<......>>...>>>>>...>>>>>>>>
>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<.....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<....
.<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<
<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....
>>>.........>>....>>...<<<<<........>>>>>))<<<<..<
<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<
<<<<<....(..>>>>>>....<<<<<...<<<<<<....<<<.....>>
>....>>>>>>.....>>>>>.....<<<<<<<<.....>>>>>>>>>>>
>...>>>>>>>.>>>>........>>>>>>........>>>.>>>>>>>>
..>>.....<<......>>>>>>>.<<<<..>>>>..>>>>..<<<<...
..<<<<<<<.<<.........<.....<<<<<<>>>>>>...>..>>.>>
>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<
..<<.........<<<<<<...<..>...>>>>>><<<..<<<<<..<.<
<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>>>>>.....
.>>.>>>>>.....<<<<<<<<..<<<<.<.<<<<<..............
...>>>>>.><<<<<...<<<<...<<<<<<<<<<.)....>>>>..>>>
>>>..>>>>..>>>>>.<<<<....<<<<...........>>>>....>>
>>.>>>>....>>>>>>>>...<<.......<<<<..>>>>....>>...
.....<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>
>.........<<<<<.<.............>.....<<<<<<<<<.<<<.
...<<<..>>>...>>>....>>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8etc Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): N61 I63 S64 E65 P66 K67 P68 K70 R83 R94 A110 A111 R112 H113 R114 K131 R136 L143 N144 P145 H153 R154 R155 P169 H170 P172 T174 F175
• Binding residue (residue number reindexed from 1): N60 I62 S63 E64 P65 K66 P67 K69 R82 R93 A109 A110 R111 H112 R113 K130 R135 L142 N143 P144 H152 R153 R154 P161 H162 P164 T166 F167

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8etc, PDBe:8etc, PDBj:8etc
• PDBsum: 8etc
• PubMed: 36423630
• UniProt: P0CT68|RL20A_SCHPO Large ribosomal subunit protein eL20A (Gene Name=rpl2001)