Structure of PDB 8d8k Chain S Binding Site BS01

Receptor Information

>8d8k Chain S (length=75) Species: 4932 (Saccharomyces cerevisiae)

SRSVWKGPNIVPLPIREAMTKGTPIRTNARAATILPQFVGLKFQIHNGKE
YVPIEISEDMVGHKLGEFAPTRKRF

Ligand information

>8d8k Chain a (length=1538)

uuuuauauauauauaauaaggaaaaguauuuauaagaauaugauguuggu
ucagauuaagcgcuaaauaaggacaugacacaugcgaaucauacguuuau
uauugagauaauaaauaugugguguaaacgugaguaauuuuauuaggaau
uaaugaacuauagaauaagcuaaauacuuaauauuauauaaaaauaauuu
auauaauaaaaaggauauauauauauauauuuaucuauagucaagccaau
aaugguuuagguaguagguuuauuaagaguuaaaccuagccaacgaucca
uaaucgauaaugaaaguuagaacgaucacguugacucugaaauauaguca
auaucuauaagauacagcagugaggaauauuggacaaugaucgaaagauu
gauccaguuacuuauuaggaugauauauauauauauauaaauugauuaaa
aauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauuua
uauggauauauauauauuuuaauaguccugacuaauauuugugccagcag
ucgcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauc
cguagaaugaauuauauauaauuuagaguuaauaaaauauaauuaaagaa
uuauaauaguaaagaugaaauaauaauaauaauuauaagacuaauauaug
ugaaaauauuaauuaaauauuaacugacauugagggauuaaaacuagagu
agcgaaacggauucgauacccguguaguucuaguaguaaacuaugaauac
aauuauuuauaauauauauauaaauaauaaaugaaaaugaaaguauucca
ccugaagaguacguuagcaauaaugaaacucaaaacaauagacgguuaca
gacuuaagcaguggagcauguuauuuaauucgauaauccacgacuaaccu
uaccauauuuugaauauuauaauaauuauaauuauuauauuacaggcguu
acauuguugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaa
cgaacaaaacuccauauauauaauuuuaauuauauauaauuuuauauuau
uuauuaauauaaagaaaggaauuaagacaaaucauaaugauccuuauaau
auggguaauagacgugcuauaauaaaaugauaauaaaauuauauaaaaua
uauuuaauuauauuuaauuaauaauauaaaacauuuuaauuuuuaauaua
uuuuuuuauuauaauaugaauuauaaucugaaauucgauuauaugaaaaa
agaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacu
guuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauua
uuuauauaauauuuuuuaauaaauauuauuaauuuauauuuauuuauauc
agaaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaa
ccugcggugggcuuauaaauaucuuaaauauucuuaca

..<<<<<<..>>>>>>...................<<<<..[.((((.>>
>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<<<<<<<
<<<<..>>>>>>>>>>..>>>>>.....<<<........<<<<<.<<...
...<..<<<<<<<<.<<<<.......>>>>...<<<<<<<<<.....>>>
>>>>>>......<<<<<<<<<..>>>>>>>>>.>>>>>>>>.>..>>>>>
>><<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>
..<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>
><<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>
..>>>..>>.>>>>>>.<<<<..<<<<<<....>>>>>>..<<......>
>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..>>
>>>>>.<<<<..>>>>.>>>....<<<<<(((.....<<<<.....<<.)
))>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<
<...<.<<.<<<<<<..>>>>>>...<<<<<<<<.....<<<<<<<<<..
<<<<<<<....<...........>.......>>>>>>>..>>.......<
<....>>.>>>>>>>..>>>>>>>>...>>>...>>>>....<<<<<<..
.<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<
.<<<<<<<<<<<<..>>.>>>>>>>>>>..<<..))>>....>>>>>>.>
>>.<<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<
<......<<<<<..<<<<<<<<<<..........................
..<<<<<<<.....<<.<<<<<<<<<<..>>>>>>>>>>.>>.<<<.<<.
.<<<<<<<<<<<<..<<<<<<<<<....>>>....<<......>>....>
>>>>>.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<.
....>>>>>>>>>....>>>...>>>>>>>....>>>>>>>>>>...>>>
>>>>...>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<
<<......>>>>>>..>>....>>>......>>>>>>......<<<<<..
......>>>>>.....<....<<<<<<<........>>>>>>>....>..
...>>>>>.....<<.<<<<<.........>>>>>>>...........>>
>>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<
<..<<<.<<<<<...<<<<<<<...>>>>>>>...>>>>>>>>..>>>..
>>>>>>>>>>>>..>>>>>>>>..>.>>.>.>.....<<<<<<<<<....
>>>>>>>>>.............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d8k Principles of mitoribosomal small subunit assembly in eukaryotes.
• Resolution: 3.13 Å
• Binding residue (original residue number in PDB): S9 R10 S11 V12 W13 K14 N17 N36 R38 A39 G56 K57 K72 G74 T79 R80 F83
• Binding residue (residue number reindexed from 1): S1 R2 S3 V4 W5 K6 N9 N28 R30 A31 G48 K49 K64 G66 T71 R72 F75

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8d8k, PDBe:8d8k, PDBj:8d8k
• PDBsum: 8d8k
• PubMed: 36482135
• UniProt: P53733|RT19_YEAST Small ribosomal subunit protein uS19m (Gene Name=RSM19)