Structure of PDB 8cvo Chain S Binding Site BS01

Receptor Information
>8cvo Chain S (length=60) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTALKVKAARKPKFGVRAYTRCQRCGRPHSVYRKFGLCRICLREMAHAG
QLPGVTKSSW
Ligand information
>8cvo Chain A (length=471) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacggggccccgcacaagcggcggagcaugcggauuaauucgaugcaacg
cguagaaccuuaccuggguuugacauggaucgggagugcucagagauggg
ugugccucuuggucgguucacagguggugcauggcugucgucagcucgug
ucgugagauguuggguuaagucccgcaacgagcgcaacccuuguucacug
uugccagcacguuaugguggggacucaguggagaccgccggggucaacuc
ggaggaagguggggaugacgucaagucaucaugccccuuauguccagggc
uucacgcaugcuacaauggcugguacagagaguggcgagccugugagggu
gagcgaaucucggaaagccggucucaguucggauuggggucugcaacucg
accucaugaagucggagucgcuaguaaucgcagaucagcaacgcugcggu
gaauacguucccggggcuugu
.<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........
>>..........<<<<<<<......<<<<<.<....<<<<<<....>>>>
>>...........>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<
<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<
...<<..<<<......>>>>>....>>>>>>>.....<<<<<.....>>>
>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>..
.>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>
..>>....>>>.....>>>>>>>......<....<<<<<<<........>
>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>
......>>...>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB8cvo Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		A2 K3 T4 A5 L6 K9 K15 F16 V18 R19 Y21 R23 C27 R29 H31 S32 V33 R35 R41 I42 R45 K58 S60 W61
Binding residue
(residue number reindexed from 1)		A1 K2 T3 A4 L5 K8 K14 F15 V17 R18 Y20 R22 C26 R28 H30 S31 V32 R34 R40 I41 R44 K57 S59 W60
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cvo, PDBe:8cvo, PDBj:8cvo
PDBsum8cvo
PubMed36864821
UniProtQ6A6N9|RS14Z_CUTAK Small ribosomal subunit protein uS14B (Gene Name=rpsZ)

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