Structure of PDB 8crx Chain S Binding Site BS01

Receptor Information
>8crx Chain S (length=60) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTALKVKAARKPKFGVRAYTRCQRCGRPHSVYRKFGLCRICLREMAHAG
QLPGVTKSSW
Ligand information
>8crx Chain A (length=1505) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaa
cacaugcaagucgaacggaaaggcccuuggggugcucgaguggcgaacgg
gugaguaacacgugaguaaccugcccuugacuuugggauaacuucaggaa
acuggggcuaauaccggauaggagcuccugcugcaugguggggguuggaa
aguuucggcgguuggggauggacucgcggcuuaucagcuuguuggugggg
uaguggcuuaccaaggcuuugacggguagccggccugagagggugaccgg
ccacauugggacugagauacggcccagacuccuacgggaggcagcagugg
ggaauauugcacaaugggcggaagccugaugcagcaacgccgcgugcggg
augacggccuucggguuguaaaccgcuuucgccugugacgaagcgugagu
gacgguaauggguaaagaagcaccggcuaacuacgugccagcagccgcgg
ugauacguagggugcgagcguuguccggauuuauugggcguaaagggcuc
guaggugguugaucgcgucggaaguguaaucuuggggcuuaacccugagc
gugcuuucgauacggguugacuugaggaagguaggggagaauggaauucc
ugguggagcgguggaaugcgcagauaucaggaggaacaccaguggcgaag
gcgguucucugggccuuuccugacgcugaggagcgaaagcguggggagcg
aacaggcuuagauacccugguaguccacgcuguaaacgguggguacuagg
ugugggguccauuccacggguuccgugccguagcuaacgcuuuaaguacc
ccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggg
ccccgcacaagcggcggagcaugcggauuaauucgaugcaacgcguagaa
ccuuaccuggguuugacauggaucgggagugcucagagaugggugugccu
cuuggucgguucacagguggugcauggcugucgucagcucgugucgugag
auguuggguuaagucccgcaacgagcgcaacccuuguucacuguugccag
cacguuaugguggggacucaguggagaccgccggggucaacucggaggaa
gguggggaugacgucaagucaucaugccccuuauguccagggcuucacgc
augcuacaauggcugguacagagaguggcgagccugugagggugagcgaa
ucucggaaagccggucucaguucggauuggggucugcaacucgaccucau
gaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacg
uucccggggcuuguacacaccgcccgucaagucaugaaaguugguaacac
ccgaagccgguggccuaaccguugugggggagccgucgaaggugggacug
gugauuaggacuaagucguaacaagguagccguaccggaaggugcggcug
gauca
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....
<<<.<<<..<<<..<<.<..<<.<<<..>>>...>>>..>>>>>......
<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<...
.>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>....
.<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<..
.......>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>
>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.
........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.
.....<<<<....>>>>.....>>>>...<<<<<<<......<<....>>
.......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>..
.....>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<
...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>.
..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<
<<<<<..<<<......>>>.....>>>>>>>>>...........<<....
>>.>>>>>>>..>>>>.>>>>...>>>...>>>>...<<<<<<<...<<.
..<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<
<<<<<<<<<<.<...>.>>>>>>>>>>>>..<<<..))>>>....>>>>>
>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<
<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.....
.....<<<<<<<......<<<<<.<....<<<<<<....>>>>>>.....
......>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>
>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..
<<<......>>>>>....>>>>>>>.....<<<<<.....>>>>>.....
...>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>
>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>...
.>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>.
...>.....>>>>>>....<<<<<<<..........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<
<....<.<<<<..<<<..<......>.>>>.>>>>.>...>>>>..>>>>
>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8crx Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		A2 K3 T4 A5 L6 K9 K15 F16 V18 R19 Y21 R23 C27 R29 H31 S32 V33 R35 R41 I42 R45 K58 S60 W61
Binding residue
(residue number reindexed from 1)		A1 K2 T3 A4 L5 K8 K14 F15 V17 R18 Y20 R22 C26 R28 H30 S31 V32 R34 R40 I41 R44 K57 S59 W60
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8crx, PDBe:8crx, PDBj:8crx
PDBsum8crx
PubMed36864821
UniProtA0A2B7JMX1

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