Structure of PDB 8c9b Chain S Binding Site BS01

Receptor Information
>8c9b Chain S (length=95) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKV
LESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRTSHITVVVSDR
Ligand information
>8c9b Chain A (length=574) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaa
ucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuu
ccgaauggggaaacccaguguguuucgacacacuaucauuaacugaaucc
auagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgag
gaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagc
agcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggc
gcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagc
ucgaugaguagggcgggacacgugguauccugucugaauauggggggacc
auccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgu
gagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaa
accguguacguuuauauucuguagcaagguuaaccgaauaggggagccga
agggaaaccgaaguugcaggguau
.<<<<<<<<<<....<.<<.<<<<<<<<<<<<<......<<<<<<.[..(
((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>
>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<......
...>>>>>>>>>.>>...<<<<<<...................>>>>>.>
.........<<....>>..<<<<.<<....<<.....>>....>>>>>>.
.<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>
>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>
>>........<<<.<<<..........>.>>.>>>......<<<<<....
.>>>>>...>>>......>>.>>>>>>>.>>...............<<..
..>>....>>.........<<<<.....>>>>.............>....
>>>>>>>>>>...<<<<<<<<<<<<..<<....<<.....>>....>>..
.<<....>>...>>>>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c9b Cryo-EM captures early ribosome assembly in action.
Resolution5.9 Å
Binding residue
(original residue number in PDB)		I4 K6 H7 H9 R18 R25 K49 E52 S53 A56 N57 H60 N61 K73 D77 E78 G79 P80 H102
Binding residue
(residue number reindexed from 1)		I4 K6 H7 H9 R18 R25 K49 E52 S53 A56 N57 H60 N61 K73 D77 E78 G79 P80 H87
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042255 ribosome assembly
GO:0042256 cytosolic ribosome assembly
GO:0046677 response to antibiotic
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8c9b, PDBe:8c9b, PDBj:8c9b
PDBsum8c9b
PubMed36797249
UniProtP61175|RL22_ECOLI Large ribosomal subunit protein uL22 (Gene Name=rplV)

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