Structure of PDB 8c9a Chain S Binding Site BS01

Receptor Information
>8c9a Chain S (length=94) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKVL
ESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRTSHITVVVSDR
Ligand information
>8c9a Chain A (length=650) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaa
ucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuu
ccgaauggggaaacccaguguguuucgacacacuaucauuaacugaaucc
auagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgag
gaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagc
agcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggc
gcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagc
ucgaugaguagggcgggacacgugguauccugucugaauauggggggacc
auccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgu
gagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaa
accguguacguacuuauauucuguagcaagguuaaccgaauaggggagcc
gaagggaaaccgaaguugcaggguauuuccuguccaacguuaaucggggc
agggugagucgaaacagguuaauauuccuguacuugguaucaaaucguac
.<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<.[..(
((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>
>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<......
...>>>>>>>>>.>>...<<<<<<...................>>>>>.>
...................<<<<<......<<.....>>.....>>>>>.
.<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>
>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>
>>........<<<.<<<<.........>>>>.>>>......<<<<<....
.>>>.>>..>>>......>>.>>>>>>>.>>...............<<..
..>>....>>.........<<<<.....>>>>.............>....
>>>>>>>>>>.....<<<<<<<<<<<<...<....<<.....>>....>.
...<<....>>...>>>>>>>>>>>>..<<<<<<...<<.....>>.>>>
>>>....<<(...<<<<<........>>>>>>><<<<..>>>>...)...
Receptor-Ligand Complex Structure
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PDB8c9a Cryo-EM captures early ribosome assembly in action.
Resolution4.86 Å
Binding residue
(original residue number in PDB)		I4 K6 R8 H9 R18 R25 K49 E52 A56 N57 H60 N61 K73 D77 E78 K98
Binding residue
(residue number reindexed from 1)		I3 K5 R7 H8 R17 R24 K48 E51 A55 N56 H59 N60 K72 D76 E77 K82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042255 ribosome assembly
GO:0042256 cytosolic ribosome assembly
GO:0046677 response to antibiotic
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8c9a, PDBe:8c9a, PDBj:8c9a
PDBsum8c9a
PubMed36797249
UniProtP61175|RL22_ECOLI Large ribosomal subunit protein uL22 (Gene Name=rplV)

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