Structure of PDB 8c92 Chain S Binding Site BS01

Receptor Information
>8c92 Chain S (length=101) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKV
LESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIRILKRTSHITVVVSD
R
Ligand information
>8c92 Chain A (length=1873) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgau
gaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguu
auaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuau
cauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacau
cuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcg
agcgaacggggagcagcccagagccugaaucaguguguguguuaguggaa
gcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaug
cacaugcugugagcucgaugaguagggcgggacacgugguauccugucug
aauauggggggaccauccuccaaggcuaaauacuccugacugaccgauag
ugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagug
aaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggc
gugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguag
caagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggc
guuaaguugcaggguauagacccgaaacccggugaccgggagauagcugg
uucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggg
uagagcaccaaacugcgaauaccggagaauguuaucacgggagacacacg
gcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcu
aaggucccaaagucaugguuaagugggaaacgcggaagauguaacggggc
uaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguag
gggagcguucuguaagccugcgaaggugugcugugaggcaugcuggaggu
aucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcc
cgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggu
gagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacaggu
uaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuau
guuggccgggcgacgguugucccgguuuaagcguguaggcugguuuucca
ggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggug
cugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucaggua
acaucaaaucguaccccaaaccgacacagguggucagguagagaauacca
aggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccggca
cgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaa
gauaccagcuggcgccaggcugucuccacccgagacucagugaaauugaa
cucgcugugaagaugcaguguacccgcggcaagaucugccgugggcgcug
gagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcau
cacugguguucggguugucaugccaauggcacugcccgguagcuaaaugc
ggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaug
aguucucccugacccuuuaaggguccugaaggaacguugaagacgacgac
guugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguac
uaaugaaccgugaggcuuaaccu
<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<...
...<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>...
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>....<<<<<.....<<....>
>......>>>>>...........<<....>>..<<<<<<.....<<....
.>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...
<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>
>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>.
.....<<<<<......>>>>>..>>>......>>.>>>>>>>.>>.....
..........<<....>>....>>.........<<<<.....>>>>....
.........>....>>>>>>>>>>>.......<<<<..<<<<<......>
>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<
<..<<<...<<.....>>...>>>....<<...>>..<<<<.....>>>>
.....>>>>>>>>>>>>>..<<.<..<<<<<<<.>>>>>>...>..>.>>
..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<...
..<<<.......>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<
<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<.
..<<<(((.....<<<<<<...........<..>...........)))..
...>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>
>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>
..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>
>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>..
..((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<.
.......>>>>>))<<<<<<<<<<<.<..<<<<<....<<<<..<<<..<
<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.
<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>
>>...>>>>>>...>>>...>>>>.........>>>>>..>.....>>>>
>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.
.>>>>..<<<<....<<<<<<<<.<..........<.....<<<<..>>>
><<<<<<.....<<<...<<<.<....>>>>...>>>...>>>>>>....
........<<<<..>>>>..>...>.>>>>>>>>.>>>>>>.....>...
..<<<<<........>>>>>..<<<<<<<<.<<..>>>>>>>>>>....<
<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<
...<<<<..<<<<<<<<<<<<))).>>>>>>..>>>>>>..>>>>.>>>>
>...<<<....<<<<<...........>>>>>....>>>.>>>>......
.>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>
>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>
>>.....>>..>..>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB8c92 Cryo-EM captures early ribosome assembly in action.
Resolution3.79 Å
Binding residue
(original residue number in PDB)		I4 K6 H7 H9 R11 S13 Q15 K16 R18 R25 K41 K42 K49 S53 A56 N57 H60 N61 D77 E78 R84 R95 I96
Binding residue
(residue number reindexed from 1)		I4 K6 H7 H9 R11 S13 Q15 K16 R18 R25 K41 K42 K49 S53 A56 N57 H60 N61 D77 E78 R84 R86 I87
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042255 ribosome assembly
GO:0042256 cytosolic ribosome assembly
GO:0046677 response to antibiotic
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8c92, PDBe:8c92, PDBj:8c92
PDBsum8c92
PubMed36797249
UniProtP61175|RL22_ECOLI Large ribosomal subunit protein uL22 (Gene Name=rplV)

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