Structure of PDB 8bea Chain S Binding Site BS01

Receptor Information

>8bea Chain S (length=449) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYH
MYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPAELKRFRKEYIQP
VQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESIT
KIIQRKKIFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDL
YRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENL
EERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPS
RQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNP
EVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLN
PMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN

Ligand information

>8bea Chain P (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cFHPWSV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8bea Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Resolution	2.47 Å
Binding residue (original residue number in PDB)	M878 Y884 F890 K898 L901 E902 H905 E906 E909
Binding residue (residue number reindexed from 1)	M283 Y289 F295 K303 L306 E307 H310 E311 E314

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005085	guanyl-nucleotide exchange factor activity

	Biological Process
GO:0007264	small GTPase-mediated signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:8bea, PDBe:8bea, PDBj:8bea
PDBsum	8bea
PubMed	37067463
UniProt	Q07889\|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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