Structure of PDB 8be7 Chain S Binding Site BS01

Receptor Information

>8be7 Chain S (length=441) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MRLPSADVYRFAEPDSEENIIFEENGIPIIKAGTVIKLIERLTYHMYADP
NFVRTFLTTYRSFCKPQELLSLIIERFEIPEPAELKRFRKEYIQPVQLRV
LNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQR
KKIFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQ
PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVA
VVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKR
HGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNS
MEKEFTDYLFNKSLEIEPRPLPRFPKKYSYPLKSPGVRPSN

Ligand information

>8be7 Chain P (length=9) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KRHPWSVAD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8be7 Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	N879 Y884 F890 K898 E902 H905
Binding residue (residue number reindexed from 1)	N279 Y284 F290 K298 E302 H305

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005085	guanyl-nucleotide exchange factor activity

	Biological Process
GO:0007264	small GTPase-mediated signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:8be7, PDBe:8be7, PDBj:8be7
PDBsum	8be7
PubMed	37067463
UniProt	Q07889\|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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