Structure of PDB 8be6 Chain S Binding Site BS01

Receptor Information

>8be6 Chain S (length=440) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFV
RTFLTTYRSFCKPQELLSLIIERFEIPEPKRFRKEYIQPVQLRVLNVCRH
WVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIITF
QSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSEL
VGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSR
IIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEA
HELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKE
LINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKE
FTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN

Ligand information

>8be6 Chain P (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RHPWSVA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8be6 Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Resolution	2.8988 Å
Binding residue (original residue number in PDB)	Y884 F890 E902 H905
Binding residue (residue number reindexed from 1)	Y280 F286 E298 H301

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005085	guanyl-nucleotide exchange factor activity

	Biological Process
GO:0007264	small GTPase-mediated signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:8be6, PDBe:8be6, PDBj:8be6
PDBsum	8be6
PubMed	37067463
UniProt	Q07889\|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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