Structure of PDB 8a98 Chain S Binding Site BS01

Receptor Information
>8a98 Chain S (length=152) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VHSYGYKSGTRHLFAKKFRKHGVPSVSTILTNIKVGDYVDVVADSAVREG
MPHKYYHGRTGIVWNVTPRGVGVIINKPVRTRTLRKRICVRFEHVRKSRC
QEAFKAKEHQFQAYLAAKKAGKALPPLQKSSRLGGIVRPKNVEVLARRVA
DY
Ligand information
>8a98 Chain 1 (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuuaaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaagagccagaaccagcccuacugca
uuauccugucgggggucaaaauccggcgggcaacgaagugcaagaggguc
uuggugaaaugagcggaguauuugagcuggcacgggcacgcacucuucuc
cgugaugcuccauguuggcgauggaaauggggugcccccacccgucuuga
aacacggaccaaggagucaaacagacgcgcaagggaggagauauggccag
uacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcac
acgucaaauccguuugauuugcccaacaccgaccggcccuccguggguug
cguuggagugugccuguuuggacccgaaagguggugaacuaugccugaac
aaggugaagcccggggaaacccagguggaggccuguagcgaugcugacgu
gcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaacca
ccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuagu
agaaguauugugcgguaaagcgauacuuuaaaugugcaaacaaaccggcc
uuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggc
cuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauau
guggcgucaaaacuuaugggcucauucucgauacguaaaggguguuggug
gccaccggccccgaaaauggaugacgcuuaaggccaauuagugaaugccc
auuauuccuuugguaagggcggaaacggagaaaguguagcccuuccgaug
uagauguggccuggagguuaggacgaagcuuauggcgugagccuaagaug
gaccggccucuagugcagaucuugguuggcguagcaaagaucuaacggag
auauacucaacaugcaacguuggauacuggagcggggaaggauuucgugc
caacggcacucguacacgaguuguucggaaacugagcacaacguuauauc
guuuuguuaggaaagugaaguacugaaaaggggcaacagagaaccuggga
uuauauuccaaaaagaaauugcauguggg
......................<<<<<......<<....>>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<.<<<<<......>>>>>..>....>>>>>
..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......(((..<<<<<<.<<<<<.....<<<<<.<<<<<<<<<...<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>...>>>>>.
.>>>>........<<<<<.....<<....<<.<..>...>>..>>..>>>
>>.....<<<<...>>>>>.....>>>>>>>>>>>..))).<<<<.....
...>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........
.>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<
<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>
.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.
.<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<...
.....>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>
>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<...
..<<...<<<<<<<...<<<.....>>.>...>>>>>>>.....<<<<<<
<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<
<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<.
..<<<<<<......[..((.(........(.........<<<.<<<<<<<
..>>>>>>>>>>..........>>>.)....).)).].........>>>.
..>>>>>>>((((.<<<<<.......>>>>.........>>>>>))))..
..>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.
....>>>>>>>>..>.....>>>>>>..............<<<<<<<...
.................>>>>>>>....................<<<<<.
...<<.....>>..>>>>>....<<..........<<.<<<<<......>
>>>...............<....>......>.>>..........<<<<..
.......>>....>>.>>...........
Receptor-Ligand Complex Structure
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PDB8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution2.46 Å
Binding residue
(original residue number in PDB)		H13 F19 H58 R60 T61 R81 R100 C101 Q102 F105 E109 Q111 F112 L116 Q129 S132 R133 R139
Binding residue
(residue number reindexed from 1)		H12 F18 H57 R59 T60 R80 R99 C100 Q101 F104 E108 Q110 F111 L115 Q128 S131 R132 R138
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum8a98
PubMed38722744
UniProtQ4QEX4

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