Structure of PDB 7wu0 Chain S Binding Site BS01

Receptor Information

>7wu0 Chain S (length=130) Species: 9606 (Homo sapiens)

LVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDL
TKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANG
LDNKLREDLERLKKIRAHRGLRHFWGLRVR

Ligand information

>7wu0 Chain 2 (length=1624)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucagauaccgucguaguuccga
ccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgc
cgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguauggu
ugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggcuuaauuugacucaacacgggaaaccucacccggcccggac
acggacaggauugacagauugauagcucuuucucgauuccguggguggug
gugcauggccguuguugguggagcgauuugucugguuaauuccgauaacg
aacgacucuggcaugcuauucuuagagggacaaguggcguucagccaccc
gagauugagcuaacaggucugugaugcccuuagauguccggggcugcacg
cgcgcuacacugacuggcucagcguguccuacgccggcaggcgcggguaa
cccguugaaccccauucgugauggggaucggggauugcaauuauucccca
ugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaag
ucccugcccuuuguacaccgcgucgcuacuaccgauuggaugguuuagug
aggcccucggaucggccccgccggggugcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucggguuuccguaggug
aaccugcggaaggaucauuaacgg

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<....<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>.....>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>
>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>
>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<
<....>>>>....>>>..)))).]..<<<.<<<<<<<..<<..<<<<<..
<<<.<<<<<<............................<<<<<.<....<
<<<<<.......<<.<<<........>>>.>>.....>>>>>>......<
<<<<<<<<<<<<.<<<.<<<<<....>>>...<<<......>>>...>>.
>>>..<<<...<...<<<....>>>..>.....<<<<<.....>>>>>..
......>>>...>>.>>>>.>>>.>>>>.......>.>>>>>...>>.>>
>>.>>>.....<<.<<<........<.<<<.<<<<....>>>>.>>>...
.>.........>>>.>>......<.....<<<<<..........>>>>>.
....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>>>>..<<<.<<.<..<<<<.<<....<<<<<<<<.<<<.
.<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>
.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>>>><<<<<<<<<..
..>>>>>>>>>.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wu0 The nucleoplasmic phase of pre-40S formation prior to nuclear export.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): F28 G35 V36 G37 R38 R39 Y40 W82 F83 N85 R86 Q87 K88 H120 R121 L129 V131 R132
• Binding residue (residue number reindexed from 1): F26 G33 V34 G35 R36 R37 Y38 W80 F81 N83 R84 Q85 K86 H118 R119 L127 V129 R130

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0014069 postsynaptic density
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7wu0, PDBe:7wu0, PDBj:7wu0
• PDBsum: 7wu0
• PubMed: 36321656
• UniProt: P62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)