Structure of PDB 7wtv Chain S Binding Site BS01

Receptor Information
>7wtv Chain S (length=126) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDL
TKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANG
LDNKLREDLERLKKIRAHRGLRHFWG
Ligand information
>7wtv Chain 2 (length=1574) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccaauuccagcuc
caauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucu
cucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
cgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuu
uguugguuuucggaacugaggccaugauuaagagggacggccgggggcau
ucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacc
agagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaaguc
ggagguucgaagacgauaccgucguaguuccgaccauaaacgaugccgac
cggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaa
accaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gacccggcccggacacggacaggauugacagauugauagcucuuucucga
uuccgugggugguggugcauggccguuguuggcugguuaauuccgaugaa
cgagacucuggcaugcuauucuuagagggacaaguggcguucagccaccc
gagauugagcuaacaggucugugaugcccuguccggggcugcacgcgcgc
uacacugacuggcucagcguguccuacgccggcaggcgcggguaacccgu
ugaaccccauucgugauggggaucggggauugcaauuauuccccaugaac
gaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccu
gcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuaguga
ggcccucggaucggccccgccggggugcccuggcggagcgcugagaagac
ggucgaacuugacuaucuagaggaaguaaaagucgagguuuccguaggug
aaccugcggaaggaucauuaacgg
...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<........<<<<........>>>>.>>
>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...
<<.<<<..>>>>>...<<<<<<.<.......<<...<.......>.<<<<
.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<....
...........>>>>>>>.>>.>....>>....<<<<<<..<...<<<<.
.<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>....
...<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<
<<<<...<...<<<<....>>>>...>>>>>>>>..........<<<.<<
.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..)
)>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>.
.)))).]]....<<<<<<<<..<<..<<<<<..<<<.<<<<<<.......
..<<<<<....<.<<<<<<.......<<.<<<........>>>.>>....
.>>>>>>..>...<<<.<<.<<<<<<.<<<...<<<......>>>...>>
>....<<<...<...<<<....>>>..>.....<<<<<.....>>>>>..
......>>>...>>.>>>>..>>..>>>....>>>>>...>>.>>>>.>>
>.....<<.<<<........<.<<<.<<<<....>>>>.>>>....>...
......>>>.>>......<.....<<<<<..........>>>>>.....>
.....>>>>>.....<<<<<<<<<.....>>>>>>>>>......>>...>
>>>>>>>......<<<...<<....<<<<.<<....<<<<<<<<.<<<..
<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.
>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.>>><<<<<<<<<..
..>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wtv The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R24 K25 F28 G35 V36 G37 R39 Y40 R55 W82 F83 N85 Q87 K88 L103 L107 H120 R121 H125
Binding residue
(residue number reindexed from 1)		R22 K23 F26 G33 V34 G35 R37 Y38 R53 W80 F81 N83 Q85 K86 L101 L105 H118 R119 H123
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wtv, PDBe:7wtv, PDBj:7wtv
PDBsum7wtv
PubMed36321656
UniProtP62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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