Structure of PDB 7syp Chain S Binding Site BS01

Receptor Information
>7syp Chain S (length=132) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIA
GYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPD
TKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRG
Ligand information
>7syp Chain 2 (length=1680) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucuugcucggcgccggcccgaagcguuuacuuugaaaaaau
uagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaa
uaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaa
gagggacggccgggggcauucguauugcgccgcuagaggugaaauucuug
gaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuuca
uuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucgua
guuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccau
gacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggggga
guaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccacca
ggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccgg
cccggacacggacaggauugacagauugauagcucuuucucgauuccgug
ggugguggugcauggccguucuuaguugguggagcgauuugucugguuaa
uuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccgg
ucggcguaacuucuuagagggacaaguggcguucagccacccgagauuga
gcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcu
acacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaa
cccguugaaccccauucgugauggggaucggggauugcaauuauucccca
ugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaag
ucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuu
agugaggcccucggaucggccccgccggggugcccuggcggagcgcugag
aagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguu
uccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<......<<....<<<<.........<<.....<<.<<.....
..>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<
...>>>>>>>..>.>>>...>>....>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....
<<<..<<<..<<<....>>>...>>>...>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<.<.<<....<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......
<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>.....
...<.<<.<<<<<<<...............>>>>>>>.>>.>....>>..
..<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>...
...>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>.
..>.>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...
>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........
>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<..
....<<<......>>>....>>>..)))).]..<...<<<<<<<..<<..
<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<
......<<<<<<........<..<<........>>.>.......>>>>>>
.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<....
..>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>
>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>
>....>>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>
.>...<<.<<<........<.......<<<.<<<<....>>>>.>>>...
.>.........>>>.>>......<.....<<<<<..........>>>>>.
....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.
<<<..<<<<.<<...<<<<<..<<..............>>....>>>>>.
..>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<
<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7syp Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		G2 R3 V4 R5 T6 K7 K10 K11 F28 K32 S43 K44 K45 N48 K49 H56 K59 R60 R63 R67 G125 N127 F128 K129
Binding residue
(residue number reindexed from 1)		G1 R2 V3 R4 T5 K6 K9 K10 F27 K31 S42 K43 K44 N47 K48 H55 K58 R59 R62 R66 G124 N126 F127 K128
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7syp, PDBe:7syp, PDBj:7syp
PDBsum7syp
PubMed35822879
UniProtG1TU13|RS17_RABIT Small ribosomal subunit protein eS17 (Gene Name=RPS17)

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