Structure of PDB 7r4x Chain S Binding Site BS01

Receptor Information
>7r4x Chain S (length=143) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDL
TKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANG
LDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT
Ligand information
>7r4x Chain 2 (length=1646) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugaccccgggggaugcgugca
uuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcgg
cgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccg
ugccuaccauggugaccacgggugacggggaaucaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccacucccgacccggggagguagugacgaaaaauaacaauaca
ggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuucc
acgaggauccauuggagggcaagucuggugccagcagccgcgguaauucc
agcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguug
gaucuugggagcgggcguccccgccuuacuuugaaaaaauuagaguguuc
aaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccggc
caugauuaagagggacggccgggggcauucguauugcgccgcuagaggug
aaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaaga
auguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagau
accgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcgu
uauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguu
ccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagg
gcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaac
cucacccggcccggacacggacaggauugacagauugauagcucuuucuc
gauuccgugggugguggugcauggccguucuuaguugguggagcgauuug
ucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacg
cgaccccgcggucggcgucccccaacuucuuagagggacaaguggcguuc
agccacccgagauugagcaauaacaggucugugaugcccuuagauguccg
gggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgc
cggcaggcgcggguaacccguugaaccccauucgugauggggaucgggga
uugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaa
gcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacu
accgauuggaugguuuagugaggcccucggaucggccccgccggggugcc
cuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaa
aagucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<..>>>...>>>><<.
.<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>
>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<......
...>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>
>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>....
.....<<<....<<<<...>>>>..>>>......>>.>.....<<<<<<<
<..<<<....>>>...>>>>.>>>>......<<..<...........>..
>>.........<<<<<((......<<<<.....<<..))>>.......>>
>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.
<<.......................<<<<<<.<.......<<...<....
...>.<<<<.>>>>...>>......>.>>>..>>>........<.<..>.
>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<...
...>>>......>>>>>>>>..>>.......<<....>>...>>>>..>.
.>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....
>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<
<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.
>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<
<<<..<<..<<<<<..<<<.<<<<........<<........>>......
....<<<<<.<....<<<<<<.......<<.<<<........>>>.>>..
...>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>.
..<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<
<<<<<....>>>>.>>>>.....>>>>..>>>>..>.....<<<<<....
.>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>
>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<
<....>>>>.>>>....>.........>>>.>>............<<<<<
..........>>>>>...........>>>>>.....<<<<<<<<......
.>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<
.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<.........
...>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>.
..>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r4x Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 angstrom resolution.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		K25 F28 K34 G35 V36 G37 R38 R39 Y40 R55 W82 F83 L84 N85 R86 Q87 K88 Q97 L103 L107 D110 H120 R121 R124 H125 R130 V131 R132 Q134 H135 T136 K137 T138 T139 G140 R141 R142 R144 T145
Binding residue
(residue number reindexed from 1)		K23 F26 K32 G33 V34 G35 R36 R37 Y38 R53 W80 F81 L82 N83 R84 Q85 K86 Q95 L101 L105 D108 H118 R119 R122 H123 R128 V129 R130 Q132 H133 T134 K135 T136 T137 G138 R139 R140 R142 T143
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7r4x, PDBe:7r4x, PDBj:7r4x
PDBsum7r4x
PubMed36951107
UniProtP62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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