Structure of PDB 7p7q Chain S Binding Site BS01

Receptor Information

>7p7q Chain S (length=114) Species: 1351 (Enterococcus faecalis)

NPLIQELTQEQLRTDIPAFRPGDTVRVHAKVVEGTRERIQLFEGVVIKRR
GAGISETYTVRKVSNGVGVERTFPLHTPRVAQIEVVRYGKVRRAKLYYLR
ALHGKAARIKEIRR

Ligand information

>7p7q Chain A (length=2901)

uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgauga
aggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuauga
uccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacu
uuucagugaauacauagcugauuagagguagacgcagagaacugaaacau
cuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacu
ccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcua
aagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauc
cugaguacggcggaacacgagaaauuccgucggaauccgcggggaccauc
ccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugag
ggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccg
ugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuug
uagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagac
ggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucgu
agacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaa
acgcacuggaggaccgaacccacguacguugaaaagugcggggaugaggu
guggguagcggagaaauuccaaacgaacuuggagauagcugguucucucc
gaaauagcuuuagggcuagccucggaauugagaaugauggagguagagca
cuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccg
aaugccauucauuuauauccgggagucagacugcgagugauaagauccgu
agucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuua
gaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacc
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacua
caccauuagguguagugguaggagagcguucuaagggcguugaaggucga
ucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagc
gaaagacaggugagaauccuguccaccguaugacuaagguuuccugggga
aggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcg
uaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuuga
gcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcau
guccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggac
aaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugc
caagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacac
agguagucgaggagaguauccuaaggugagcgagcgaacucucguuaagg
aacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucgg
ucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucu
cugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcugg
aagguuaagaggauggguuagcuucggcgaagcucagaauugaagcccca
guaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugu
cggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucuc
aacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccg
cgacaggacggaaagaccccauggagcuuuacuguaguuugauauugagu
guuuguaccacauguacaggauagguaggagccgaugagaccggaacgcu
aguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccuc
uaacccgcaccacuaaucguggugggagacagugucagaugggcaguuug
acuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccu
cagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuuga
cugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccg
gugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggg
gauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggc
accucgaugucggcucgucgcauccuggggcuguagucggucccaagggu
ugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgu
gagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagc
uguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguu
guucugccaagggcauugcuggguagcuauguagggaagggauaaacgcu
gaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuu
uaagaaaguaagaccccugagagaugaucagguagauagguuggaagugg
aaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaa
c

<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<
<<...<.<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((..
....<<<.....))>>>...>>>...>>>>>>>>>>>>>>>.>>>>..>>
>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>
>>>>..)))......]].>>>>>>>.]]...............<<....>
>....]].........<<<<....>>>>..................>>>>
>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<....
....>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>
...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>
>..<<.<...<<<.<<.....<<<<<<<<<..<<<....<<<<<<.....
.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>
>>>>>>...<<<.....>>>......>>.>>>......>.>>..<<<<<<
....<<<<<....>>>>><<<<<<<<.<...<<<<<<<<<.....<<<..
.<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.
....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>
>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
<...........<<..<<<<<<<<<........<<<<<.<<...<<<<..
.....>>>>...>>.........<<......>>...>>>>>....>>>>>
>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<
<<<<....>>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.
<<....>>.>>>>>...>>.>>>>>>>........>>>>>>.......<<
....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<..
.<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>.
..>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......
<<...<<<<....<<<<..<<...<<<<<.<<<<<<...(((....>>>>
>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>
..>>>>>...>>...<<.........>>....>>>>>....>>...>>>>
.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<.....
.>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.
..............<<<<<...............>>>>><<<<<<....>
>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<
..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>
>>..>>>>><<<<<<.......>>>>>>........<...........<<
<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.
>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<
<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.
<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<...
.>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.>>>
....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<
<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<.
..<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...
<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<
<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>
.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.
<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<..
..>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<
<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<
<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<
...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<..
...>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<..
..<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7p7q Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): N2 P3 R21 R51 S56 T58 K91 R93 R94 A95 K96 Y98 Y99
• Binding residue (residue number reindexed from 1): N1 P2 R20 R50 S55 T57 K90 R92 R93 A94 K95 Y97 Y98

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7p7q, PDBe:7p7q, PDBj:7p7q
• PDBsum: 7p7q
• PubMed: 35387982
• UniProt: Q833P5|RL19_ENTFA Large ribosomal subunit protein bL19 (Gene Name=rplS)