Structure of PDB 6zxg Chain S Binding Site BS01

Receptor Information
>6zxg Chain S (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADID
LTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLAN
GLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRR
Ligand information
>6zxg Chain 2 (length=1651) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucauuaa
aucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcgc
ggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgc
cgugccuaccauggugaccacgggugacggggaaucaggguucgauuccg
gagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgc
gcaaauuacccacucccgacccggggagguagugacgaaaaauaacaaua
caggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuu
uaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauu
ccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguagu
uggaucucucucggccgaagcguuuacuuugaaaaaauuagaguguucaa
agcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcggu
ucucggaacugaggccaugauuaagagggacggccgggggcauucguauu
gcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcga
aagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguu
cgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccg
gcgaugcggcggcguuauaugacccgccgggcagcuuccgggaaaccaaa
gucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaa
uugacggaagggcaccaccaggaguggagccugcggcuuaauuugacuca
acacgggaaaccucacccggcccggacacggacaggauugacagauugau
agcucuuucucgauuccgugggugguggugcauggccguucuuaguuggu
ggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcu
aacuaguuacgcgacccccggucggcguaacuucuuagagggacaagugg
cguucagccacccgagauugagcaauaacaggucugugaugcccuuagau
guccggggcugcacgcgcgcuacacugacuggcucagcgugugccuaccc
uacgccggcaggcgcggguaacccguugaaccccauucgugauggggauc
ggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggu
cauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucg
cuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggg
gugcccuggcggagcgcugagaagacggucgaacuugacuaucuagagga
aguaaaagucguaacaagguuuccguagguaaaccugcggaaggaucauu
a
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<......
..<<<.<....<<....<<<<<.........<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<.<......>.>>>...>>
>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<..>
>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<....
.....>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>
.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>..
.......<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<
<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>
..>>.........<<<<<((......<<<<.....<<..))>>.......
>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<
<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<......
.>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<
<<<.>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<
<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<..
..>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...
<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<
<<..<.<<<<<<.<<<<<>>>>>>>>>>>.>..>>>...<<..))>>...
>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).
]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<.....
...>>..........<<<<<......<<<<<<.......<<.<<<.....
...>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<
<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<
<<..<<<<<<<<<<<<...>>>>.>>>>>>>>..>>>>..>.....<<<<
<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....
..>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<
<.<<<<....>>>>.>>>....>.........>>>.>>......<.....
<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.
......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
.<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<.<<
<..>>>.>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.
>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zxg Structural basis for the final steps of human 40S ribosome maturation.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K25 F28 G35 V36 G37 R38 R39 Y40 R55 W82 F83 N85 R86 Q87 K88 L107 H120 R121 R124 H125 L129 R130 V131 R132 Q134 H135 T136 K137 T138 T139 R141 R142
Binding residue
(residue number reindexed from 1)		K24 F27 G34 V35 G36 R37 R38 Y39 R54 W81 F82 N84 R85 Q86 K87 L106 H119 R120 R123 H124 L128 R129 V130 R131 Q133 H134 T135 K136 T137 T138 R140 R141
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zxg, PDBe:6zxg, PDBj:6zxg
PDBsum6zxg
PubMed33208940
UniProtP62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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