Structure of PDB 6s0x Chain S Binding Site BS01

Receptor Information
>6s0x Chain S (length=103) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HIKKGDNVKVIAGKDKGKEGKVIATLPKKDRVVVEGVNIMKKHQKPTQLN
PEGGILETEAAIHVSNVQLLDPKTNEPTRVGYKFVDGKKVRIAKKSGEEI
KSN
Ligand information
>6s0x Chain A (length=2905) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauaugugaauacauagcauaucagaaggcacacccggagaacugaaaca
ucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggc
gagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguugua
ggacacucuacggaguuacaaaggacgacauuagacgaaucaucuggaaa
gaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuu
gaguggauccugaguacgacggagcacgugaaauuccgucggaaucuggg
aggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccag
uaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaac
cugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcg
ugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagc
aguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguau
uuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguu
cagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcg
gaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugg
uucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagg
uagagcacuguuuggacgaggggccgguuaccgaauucagacaaacuccg
aaugccaauuaauuuaacuugggagucagaacaugggugauaagguccgu
guucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuua
gaagcagccaucauuuaaagagugcguaauagcucacuagucgagugaca
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauug
uccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucg
uaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaa
agacgggugagaaucccguccaccgauugacuaagguuuccagaggaagg
cucguccgcucuggguuagucggguccuaagcugaggccgacaggcguag
gcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaauc
gauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacguc
uaagcaguaaggcugaguauuaggcaaauccgguacucguuaaggcugag
cugugauggggagaagacauugugucuucgagucguugauuucacacugc
cgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacac
agguagucaagaugagaauucuaaggugagcgagcgaacucucguuaagg
aacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggg
uuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaa
aaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccu
gcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacga
aucgaagccccaguaaacggcggccguauaacgguccuaagguagcgaaa
uuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggc
acugucucaacgagagacucggugaaaucauaguaccugugaagaugcag
guuacccgcgacaggacggaaagaccccguggagcuuuacuguagccuga
uauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacg
ugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcugugu
uggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgg
gcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaa
gguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagg
gagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuua
gugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcu
accccggggauaacaggcuuaucucccccaagaguucacaucgacgggga
gguuuggcaccucgaugucggcucaucgcauccuggggcuguagucgguc
ccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucag
aacgucgugagacaguucggucccuauccgucgugggcguaggaaauuug
agaggagcuguccuuaguacgagaggaccgggauggacauaccucuggug
uaccaguugucgugccaacggcauagcuggguagcuauguguggacggga
uaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucc
caacuucgguuauaagaucccucaaagaugaugagguuaauagguucgag
guggaagcauggugacauguggagcugacgaauacuaaucgaucgaagac
uuaau
<<<<<<......<<<<<<<<<<<....[.....[<<<<<<.[..<.....
.<<<.<<.[...((.>>......<<<<<<<..<<.))...]..>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
<<<<<.............>>>>>.>>.>.....<<<<<......<.....
.>.......>>>>.>.........<<....>>...<<<<......<<...
..>>.....>>>>...<<.....<<<<<<<<....>>>>>>>>......<
<<<<<<...........................<<<....<<<<......
>>>>.........<<<.......>>>...>>>..................
..>>>..>>>>......<..<<<..........>>>..>........<<<
<<..<<<<>>>>>...>>.......]..>>>>>>.]..............
..<<....>>................<<<....>>>..............
]....>>>>>>>>>>>..<....<<<...<<..........>>...>>>.
....<........>...<<<<.<....<<<<<<..<<<<...<.<...<<
<.....>>>...>.>...<<....>>..<<<<.....>>>>......>>>
>..>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<
<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>
>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>
...<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<....
<.......<<<<<<<<...<<.........>>...>>>>>>>>.......
.>..>.>>.>>>>...>>>>>>>.>>...<<<<.<<<<......>>>>.>
>>>.....<<<......>>>...<<<<..<<...<<<........<<<<<
<...........<<....<...<<<........<<.....<...<<<...
......>>>...>..........................>>....>>>..
.>...>>...................>>>>>>.>>>...>>.>>>>.<<<
<.......>>>>.....>>>>>...<<.<<<<.<.......<<<<<.<..
....>.>>>>>....>.>>>>>>.........>.>>>>.......<....
.<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<.<<...<<
.....>>.>>.>>>....((<<<<.<<...<<<...<<<....>>>...>
>>...>>...<<<<<........>>>>>))<<<<<<<...........<<
...<<<<....<<<<..<<<...<....<.<<....{.{....>>.>.<<
...<<<<...<<<.<<<<<<..<<.....>>.>>>>>>......>>>...
>>>>....>>..........................>...>>>...>>>>
.........>>>>..>>......>>>>>>>>>>>.>>>.....<<.....
.>>>>>>>.<<<<....>.>>>..>>>>...<<<.....<.<..<..<<.
........<.....<<<<<....<....>.....>>>>><<<<<<<.<<.
.......>>.>>>>>>>............<<<<<<<<<..<<<.......
..>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.
<<<..<<<<<<<...<<...<<...<<<<<.............>>>>>..
.>>...>>.>>>>>..>>>>>.<<<<.....>>>>.........<.....
......<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>
..>..>>.>..>.>...>>>..>...........<<<............>
>>>.<<<<<<<<.[[..[[......<<<..[[<<<<..<<<<<.<<<<<<
<<<.<<<<.<<<<....<<...............<<..............
.<<........>>......................>>......>>..>..
>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>
>>>>>....<<....<<......>>....>>..<<<....>>>.>>)))]
......<<<<<<.<<<..>>>>..>>>>>>>>>.............>>>>
..]].>>>........<<<.<.<<<<<<...<<.......>>...>>>>>
>...>>>>.........<<<<<.<..<<<..<<<<<<<<<......>>>>
>>..>>>.<<<<<.....>>>>>.....>>>....>...>>>.>>....<
<<<<<<....>>>.>>>>....]]...]]>>>>>>>>......<<<<<..
.<.<<...<<<<<<...............>>>>>>..<<<<<...<<<<.
..<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<.
...<<<<<...........>>>>>....>>>.>>.>.......>>>>>..
...............<<<<<<<<<.......>>>>>....<<<<<<<<.<
<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>
>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6s0x Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant.
Resolution2.425 Å
Binding residue
(original residue number in PDB)
K4 G14 K15 T26 R32 M41 K42 K43 H44 Q45 K46 P47 G54 G55 I56 H64 R80 Y83 K90 K95
Binding residue
(residue number reindexed from 1)
K3 G13 K14 T25 R31 M40 K41 K42 H43 Q44 K45 P46 G53 G54 I55 H63 R79 Y82 K89 K94
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6s0x, PDBe:6s0x, PDBj:6s0x
PDBsum6s0x
PubMed31391518
UniProtW8TRD5

[Back to BioLiP]