Structure of PDB 6px3 Chain S Binding Site BS01

Receptor Information

>6px3 Chain S (length=233) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSKLPPPQLFNEACRTFQVISDCLYGSRSSDHDALDCDCAEDWRDGKNHA
CGEDSDCINRATKIECVIGDCNCGEGCQNQRFQRKQYAKVSVIKTEKKGY
GLRADTDLQPNDFIYEYVGEVINEPTFRSRMLKYDKEGIKHFYFMSLTKN
EFVDATKKGNLGRFCNHSCNPNCYVDKWVVGDKLRMGIFAARYIKAGEEL
VFNYNVDRYGADPQPCYCGEPNCVGFIGGKTQT

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6px3 Chain S Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6px3 Nucleosome and ubiquitin position Set2 to methylate H3K36.
Resolution	4.1 Å
Binding residue (original residue number in PDB)	C158 C163
Binding residue (residue number reindexed from 1)	C66 C71
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046975	histone H3K36 methyltransferase activity
GO:0140955	histone H3K36 trimethyltransferase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0032259	methylation

	Cellular Component
GO:0005634	nucleus
GO:0005694	chromosome

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External links

PDB	RCSB:6px3, PDBe:6px3, PDBj:6px3
PDBsum	6px3
PubMed	31439846
UniProt	G0S676

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