Structure of PDB 6la8 Chain S Binding Site BS01

Receptor Information
>6la8 Chain S (length=74) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIK
RLVTTGVLKQTKGVGASGSFRLAK
Ligand information
>6la8 Chain I (length=349) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctggaaaaaaaaaacgcatcccggtgccgaggccgctcaattggtcgt
agacagctctagcaccgcttaaacgcacgtacgcgctgtctaccgcgttt
taaccgccactagaagcgcttactagtctccaggcacgtgtgagaccggc
acatgaaaaaaaaaagcatgctcgagtatgaaaaaaaaaacgcatcccgg
tgccgaggccgctcaattggtcgtagacagctctagcaccgcttaaacgc
acgtacgcgctgtctaccgcgttttaaccgccactagaagcgcttactag
tctccaggcacgtgtgagaccggcacatgaaaaaaaaaaccagcggtac
Receptor-Ligand Complex Structure
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PDB6la8 Near-atomic resolution structures of interdigitated nucleosome fibres.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		P26 K27 Y28 K59
Binding residue
(residue number reindexed from 1)		P3 K4 Y5 K36
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0030261 chromosome condensation
GO:0031507 heterochromatin formation
GO:0045910 negative regulation of DNA recombination
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0015629 actin cytoskeleton
GO:0016604 nuclear body
GO:0017053 transcription repressor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6la8, PDBe:6la8, PDBj:6la8
PDBsum6la8
PubMed32958761
UniProtP07305|H10_HUMAN Histone H1.0 (Gene Name=H1-0)

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