Structure of PDB 6la2 Chain S Binding Site BS01

Receptor Information
>6la2 Chain S (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSI
KRLVTTGVLKQTKGVGASGSFRLAK
Ligand information
>6la2 Chain I (length=343) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctgaaaaaaaacgcatcccggtgccgaggccgctcaattggtcgtaga
cagctctagcaccgcttaaacgcacgtacgcgctgtctaccgcgttttaa
ccgccactagaagcgcttactagtctccaggcacgtgtgagaccggcaca
tgaaaaaaaaaagcatgctcgagtatgaaaaaaaaaacgcatcccggtgc
cgaggccgctcaattggtcgtagacagctctagcaccgcttaaacgcacg
tacgcgctgtctaccgcgttttaaccgccactagaagcgcttactagtct
ccaggcacgtgtgagaccggcacatgaaaaaaaacagcggtac
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6la2 Engineering nucleosomes for generating diverse chromatin assemblies.
Resolution3.89 Å
Binding residue
(original residue number in PDB)		R47 K69 K73 A89 R94
Binding residue
(residue number reindexed from 1)		R25 K47 K51 A67 R72
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0030261 chromosome condensation
GO:0031507 heterochromatin formation
GO:0045910 negative regulation of DNA recombination
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0015629 actin cytoskeleton
GO:0016604 nuclear body
GO:0017053 transcription repressor complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6la2, PDBe:6la2, PDBj:6la2
PDBsum6la2
PubMed33590100
UniProtP07305|H10_HUMAN Histone H1.0 (Gene Name=H1-0)

[Back to BioLiP]