Structure of PDB 6gc4 Chain S Binding Site BS01

Receptor Information
>6gc4 Chain S (length=110) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKV
LESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRT
SHITVVVSDR
Ligand information
>6gc4 Chain A (length=2586) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgau
gaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguu
auaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuau
cauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacau
cuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcg
agcgaacggggagcagcccagagccugaaucaguguguguguuaguggaa
gcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaug
cacaugcugugagcucgaugaguagggcgggacacgugguauccugucug
aauauggggggaccauccuccaaggcuaaauacuccugacugaccgauag
ugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagug
aaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggc
gugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguag
caagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggc
guuaaguugcaggguauagacccgaaacccggugaucuagccaugggcag
guugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaa
aaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccggga
gauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucau
cuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaa
cccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacgg
cgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcua
aggucccaaagucaugguuaagugggaaacgaugugggaaggcgucggcc
ugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcg
acgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggug
ugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaagua
acgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccugu
ccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaag
gcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcg
aaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuu
aagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggc
gugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccagg
aaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacaca
gguggucagguagagaauaccaaggcgcuugagagaacucgggugaagga
acuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguag
gugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggc
ugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacgu
auacggugugacgccugcccgguguaaacggcggccguaacuauaacggu
ccuaagguagcgaauggcguaaugauggccaggcugucuccacccgagac
ucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacg
gaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuu
gauguguaggauaggugggaggcuuugaaguguggacgccagucugcaug
gagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugac
ccguaauccggguugcggacagugucugguggguaguuugacuggggcgg
ucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccugguc
ggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgu
gacggcgcgagcaggugcgaaagcaggucauagugauccggugguucuga
auggaagggccaucgcucaacggauaaaagguacuccggggucccuaucu
gccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggacc
ggaguggacgcaucacugguguucggguugucaugccaauggcacugccc
gguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaac
uugccccgagaugaguucucccugacccuuuaaggguccugaaggaacgu
ugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguug
agcuaaccgguacuaaugaaccgugaggcuuaaccu
<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<...
...<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>...
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>
>......>>>>>.>.........<<....>>..<<<<<<.....<<....
.>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...
<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>
>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>.
.....<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]].....
..........<<....>>....]].........<<<<.....>>>>....
.........}....>>>>>>>>>>>.......<<<<..<<<<<......>
>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<
<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>
.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<
<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<......
..>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>.
.....>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<
<<<<<<......<<...<<<.<<<<......<<.........>>......
.>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<
<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<<..<<..>>..>>
>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<
..<......>..>>>>>....>>>>>><<<<<<<...<<<......<<<<
<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......
<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<
<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>
>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<.
..<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<
..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>
>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>....
.....>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......
>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<..
.............<<<<<....<<..>>.....>>>>><<<<<<.....<
<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<
<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.....
..>>>>>>>.<<<<<.<<<..<<....>>>>>.<<<<<.......>>>>>
...............>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>
>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[
[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<
<<...........<<<<<..<<<......<<<<.<<<....>>>.>>>>.
..>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<
<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<.......>
>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..
.....>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<
....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..
>>>>..))>>>>>>>.............>>>>..]]>>>>...]]..)))
>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............
>>>>>>>.<<<<<....<<<...<<<<<<<<<<<))).>>>>>>..>>>>
>...>>>..>>>>>...<<<....<<<<<...........>>>>>....>
>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<
<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>..
.>>...>>>>>.>>>.....>>..>..>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gc4 Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		I4 K6 H7 H9 R11 S13 Q15 K16 R18 R25 K41 K42 K49 S53 A56 N57 H60 N61 F75 D77 E78 G79 P80 K83 P87 R88 A89 K90 G91 R92 A93 D94 L97 K98 R99
Binding residue
(residue number reindexed from 1)		I4 K6 H7 H9 R11 S13 Q15 K16 R18 R25 K41 K42 K49 S53 A56 N57 H60 N61 F75 D77 E78 G79 P80 K83 P87 R88 A89 K90 G91 R92 A93 D94 L97 K98 R99
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042255 ribosome assembly
GO:0042256 cytosolic ribosome assembly
GO:0046677 response to antibiotic
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gc4, PDBe:6gc4, PDBj:6gc4
PDBsum6gc4
PubMed29883607
UniProtP61175|RL22_ECOLI Large ribosomal subunit protein uL22 (Gene Name=rplV)

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