Structure of PDB 6fec Chain S Binding Site BS01

Receptor Information
>6fec Chain S (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKI
YKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGH
DILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILIL
QNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEY
IVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVL
KVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG
VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEG
DKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVG
EKIALSRRVEKHWRLIGWGQIR
Ligand information
>6fec Chain N (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgau
ggaucgaaaccauccucugcuacca
....<<<..<<<.........>>>..<<<<.......>>>>.......<<
<<.......>>>>.>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fec Structure of a human cap-dependent 48S translation pre-initiation complex.
Resolution6.3 Å
Binding residue
(original residue number in PDB)		R81 F82 Y96 F275 D276 K279 P280 G281 V291 S333 F335 G351 R362 A363
Binding residue
(residue number reindexed from 1)		R30 F31 Y45 F224 D225 K228 P229 G230 V240 S282 F284 G300 R311 A312
Enzymatic activity
Catalytic site (original residue number in PDB) A64 K67 S68 T91 H151
Catalytic site (residue number reindexed from 1) A13 K16 S17 T40 H100
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6fec, PDBe:6fec, PDBj:6fec
PDBsum6fec
PubMed29401259
UniProtP41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)

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