Structure of PDB 6epe Chain S Binding Site BS01

Receptor Information
>6epe Chain S (length=476) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PAPQDVEMKEEAAAGSGSAGEGDGKAAATEHSQRELDTVTLEDIKEHVRQ
LEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVHGFFTSNNATRDFL
LPFLEEPMDTEADLQFRPRTGKAASAPLLPEVEAYLQLLMVIFLMNSKRY
KEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFL
HARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQAN
NNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKL
LIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQ
FGEKFQTDGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSP
EDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRIS
FCLDIHNMSVKAMRFPPKSYNKDLES
Ligand information
>6epe Chain Y (length=24) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NVEDDFSNQLRAELEKHGYKMETS
Receptor-Ligand Complex Structure
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PDB6epe In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Resolution12.8 Å
Binding residue
(original residue number in PDB)		R341 Q361
Binding residue
(residue number reindexed from 1)		R314 Q334
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0030234 enzyme regulator activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005838 proteasome regulatory particle
GO:0008541 proteasome regulatory particle, lid subcomplex
GO:0022624 proteasome accessory complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6epe, PDBe:6epe, PDBj:6epe
PDBsum6epe
PubMed29398115
UniProtA6HIT6

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