Structure of PDB 5zwn Chain S Binding Site BS01

Receptor Information
>5zwn Chain S (length=131) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYFQNLPSRPANKENYTRLLLKHINPNNKYAINPSLPLPHNKLLDDQMG
LLEVSISRSSKMTNQAFLTFVTQEEADRFLEKYTTTALKVQGRKVRMGKA
RTNSLLGLSIEMQKTYNLDIKKVLKARKLKR
Ligand information
>5zwn Chain P (length=480) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auacuuaccuuaagauaucagaggaaaguccuacugaucaaacaugcgcu
uccaauaguagaaggacguuaagcauuuaucauugaacuaguucauugaa
gucauugaugcaaacuccuuggucacacacacggcgcggaaggcguguuu
gcugacguuuccauucccuuguuucaaucauugguuaaucccuuuggguu
aaacugauuuuuggggcccuuuguuucuucugccuggagaaguuugacac
caaauucaaauugguguuaggggagcuggggccuuucaaaagagcuuugu
agaggcauucuuuuugacuacuuuucgcgugccauuuuaguuuuugacga
uucgaaugaacuaguuuaugaugaaguugagauuauuuggucgauuguag
uuugaagauguagucucaacuuugcucaaauuuuggaaggucuugguagg
aacggguggaucuuauaauuuuugauuuau
...........<<<<.<<<<<<<<.....>>>.>>>>><<<<<<<<<.<<
<<<........<<<<<.<<<..<<<<.<.<<<.<<<<<..>>>>>.>>>.
......>>>>>.>>>>>>>>.................>>>>>>>>>>>>>
><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.<.<<<...>>>.>
.>>>>>>>..>>>>>>>((.......<<<<<....))>>>>>...<<<<<
<<<.......>>>>>>>>.>>>>><<<<<<<<<<<<<<<<<..<<...<<
.<<<<<..<<<<<..<<<<<<..<<.....<<<<...<<<<<<..<<<..
<<<<.<<<<<<<>>>>>>>..>>>>>>>.>>>>>>..>>>>.>>..>>>>
>>.>>>>>....>>>>>.>>...>>.....>>>>>>>>>>>>>>>>>.>>
>>>>..>>>.>>>>................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5zwn Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Resolution3.4 Å
Binding residue
(original residue number in PDB)		Y5 Q7 R12 P13 A14 N15 K16 S66 I67 S68 R69 K72 N75 Q76 F78 K100 Q102 G103 R104 K105 L116 K139
Binding residue
(residue number reindexed from 1)		Y3 Q5 R10 P11 A12 N13 K14 S55 I56 S57 R58 K61 N64 Q65 F67 K89 Q91 G92 R93 K94 L105 K122
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5zwn, PDBe:5zwn, PDBj:5zwn
PDBsum5zwn
PubMed29794219
UniProtP32605|RU1A_YEAST U1 small nuclear ribonucleoprotein A (Gene Name=MUD1)

[Back to BioLiP]