Structure of PDB 5wvi Chain S Binding Site BS01

Receptor Information

>5wvi Chain S (length=353) Species: 559292 (Saccharomyces cerevisiae S288C)

KTIEVTAEINCFMHLLVQLFLWDSKELEQLVEFNRKVVIPNLLCYYNLRS
LNLINAKLWFYIYLSHETLARSSEEINSDNQNIILRSTMMKFLKIASLKH
DNETKAMLINLILRDFLNNGEVDSASDFISKLEYPHTDVSSSLEARYFFY
LSKINAIQLDYSTANEYIIAAIRKAPHNSKSLGFLQQSNKLHCCIQLLMG
DIPELSFFHQSNMQKSLLPYYHLTKAVKLGDLKKFTSTITKYKQLLLKDD
TYQLCVRLRSNVIKTGIRIISLTYKKISLRDICLKLNLDSEQTVEYMVSR
AIRDGVIEAKINHEDGFIETTELLNIYDSEDPQQVFDERIKFANQLHDEY
LVS

Ligand information

>5wvi Chain Y (length=27) Species: 559292 (Saccharomyces cerevisiae S288C)

ENWDDVEVDDDFTNELKAELDRYKREN

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5wvi High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx
• Resolution: 6.3 Å
• Binding residue (original residue number in PDB): D326 P328 T349
• Binding residue (residue number reindexed from 1): D201 P203 T224

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding
• GO:0030234 enzyme regulator activity

Biological Process

• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0042176 regulation of protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0008541 proteasome regulatory particle, lid subcomplex

External links

• PDB: RCSB:5wvi, PDBe:5wvi, PDBj:5wvi
• PDBsum: 5wvi
• PubMed: 28106073
• UniProt: P40016|RPN3_YEAST 26S proteasome regulatory subunit RPN3 (Gene Name=RPN3)