Structure of PDB 5cd4 Chain S Binding Site BS01

Receptor Information
>5cd4 Chain S (length=353) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKS
GYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGISAD
AVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIRVNLQQGVD
IALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFTAVDDLQEQ
GSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVHMLA
TEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQPSI
QAFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWVRN
NGE
Ligand information
>5cd4 Chain X (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auaaaccgacgguauuguucagauccuggcuugccaacaggaguuccccg
cgccagcgggg
.............................................<<<<<
<....>>>>>>
Receptor-Ligand Complex Structure
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PDB5cd4 Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		N19 R20 D21 D22 K27 Q42 S43 K45 R46 R165 M166 A167 K177 D179 F200 T201 V203 Q234 A265 K266
Binding residue
(residue number reindexed from 1)		N18 R19 D20 D21 K26 Q41 S42 K44 R45 R156 M157 A158 K168 D170 F191 T192 V194 Q225 A256 K257
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cd4, PDBe:5cd4, PDBj:5cd4
PDBsum5cd4
PubMed26243775
UniProtQ46899|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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