Structure of PDB 4p6z Chain S Binding Site BS01

Receptor Information
>4p6z Chain S (length=147) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MMRFMLLFSRRGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFL
EWRDLKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCE
LDIIFNFEKAYFILDEFLMGGDVQDTSKKSVLKAIEQADLLQEEDES
Ligand information
>4p6z Chain V (length=10) Species: 11691 (Human immunodeficiency virus type 1 (SF162 ISOLATE)) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DQEELSALVE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4p6z Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R11 Y62 V98 C99 L101
Binding residue
(residue number reindexed from 1)		R11 Y62 V98 C99 L101
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0035615 clathrin adaptor activity
Biological Process
GO:0006886 intracellular protein transport
GO:0006898 receptor-mediated endocytosis
GO:0009615 response to virus
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0060155 platelet dense granule organization
GO:0110010 basolateral protein secretion
GO:1903232 melanosome assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005905 clathrin-coated pit
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030121 AP-1 adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032588 trans-Golgi network membrane
GO:0043231 intracellular membrane-bounded organelle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4p6z, PDBe:4p6z, PDBj:4p6z
PDBsum4p6z
PubMed24843023
UniProtP61966|AP1S1_HUMAN AP-1 complex subunit sigma-1A (Gene Name=AP1S1)

[Back to BioLiP]