Structure of PDB 3a5m Chain S Binding Site BS01

Receptor Information
>3a5m Chain S (length=123) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTCLYGDFFTGDAYVILKTVQL
RNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFE
SATFLGYFKSGLKYKKGGVASGF
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3a5m Chain S Residue 128 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3a5m Structural basis for actin assembly, activation of ATP hydrolysis, and delayed phosphate release
Resolution2.4 Å
Binding residue
(original residue number in PDB)		G43 D44 E75 V123
Binding residue
(residue number reindexed from 1)		G39 D40 E71 V119
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:3a5m, PDBe:3a5m, PDBj:3a5m
PDBsum3a5m
PubMed20946985
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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