Structure of PDB 2wpm Chain S Binding Site BS01

Receptor Information
>2wpm Chain S (length=235) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNFNAAINTYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRAALVLQYLRVPL
VDRATCLRSTKFTITNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2wpm Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H57 Y99 D189 S190 S195 W215 G216 E217
Binding residue
(residue number reindexed from 1)		H41 Y86 D179 S180 S185 W205 G206 E207
Enzymatic activity
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wpm, PDBe:2wpm, PDBj:2wpm
PDBsum2wpm
PubMed20004170
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

[Back to BioLiP]