Structure of PDB 2wpi Chain S Binding Site BS01

Receptor Information
>2wpi Chain S (length=235) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINTYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTITNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Ligand information
Receptor-Ligand Complex Structure
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PDB2wpi Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Resolution1.99 Å
Binding residue
(original residue number in PDB)		H57 Y99 F174 D189 S190 C191 G193 S195 S214 W215 G216
Binding residue
(residue number reindexed from 1)		H41 Y86 F162 D179 S180 C181 G183 S185 S204 W205 G206
Enzymatic activity
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2wpi, PDBe:2wpi, PDBj:2wpi
PDBsum2wpi
PubMed20004170
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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