Structure of PDB 2qkk Chain S Binding Site BS01

Receptor Information
>2qkk Chain S (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQR
AEIHAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKTSA
GKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2qkk Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Resolution3.2 Å
Binding residue
(original residue number in PDB)		N210 M212 P262 G263 R278
Binding residue
(residue number reindexed from 1)		N76 M78 P128 G129 R144
Enzymatic activity
Catalytic site (original residue number in PDB) D145 G146 E186 N210 H264 D274
Catalytic site (residue number reindexed from 1) D11 G12 E52 N76 H130 D140
Enzyme Commision number 3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2qkk, PDBe:2qkk, PDBj:2qkk
PDBsum2qkk
PubMed17964265
UniProtO60930|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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