Structure of PDB 6lqq Chain RY Binding Site BS01

Receptor Information

>6lqq Chain RY (length=37) Species: 559292 (Saccharomyces cerevisiae S288C)

KGRKLNYSVQDPIANYEAPITSGYKWSDDQIDEFFAG

Ligand information

>6lqq Chain SA (length=1323)

aagauaguuaucugguugauccugccaguagucauaugcuugucucagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucau
uaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauu
cuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauu
agaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcaugg
ccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgau
gguaggauaguggccuaccaugguuucaacggguaacggggaauaagggu
ucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggc
agcaggccaaauuacccaauccuaauucagggagguagugacaauaaaua
acgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaa
uaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguagu
ugaacuggcccgguuggccgguccggauuuccaacggggccuugguucua
uuuucuaggacugauuaauagggacggucgggggcaucaguauucaauug
ucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcau
uugccaaggacguuuucauuaaucaagaacgaccauaaacuaugccgacu
agggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaac
uggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaaggg
caccaccaggaguggagccugcggcucaacacggggaaacucaccagguc
cagacacaauaaggauugacauucuugauuuugugggugguggugcauug
augcccuuguucugggccacgcgcgcuacacugacggagccagcgagucu
aaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggc
aacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacguc
ccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuag
ugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcgg
agaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagg
uuuccguaggugaaccugcggaa

............................<<<<.<<<<<<........<<<
.<<...<<....<<....<<..........>>...>>.>>.....<<<..
.....<<<..<<..<<....<<<..........<.....<<.<<......
.>>.>>......>.......<<<<............>>>>.....<<<<<
...<<<<..............>>>>...>>>>>.........<<<<...<
<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<
<<<<<<.......>>>>>>>>>>>......>>>.....<<..........
.....>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>..
..>>>>>......<<<....<<<.....>>>..>>>..............
.<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<.......
....>..>>.........<<<<<<.......<<<....>>>.........
.........>>>>>>..>>>>>>>>>>.........<....<.<<...<<
<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>.<..<<..<
...>..>>.>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<
...<<<......>>>......>.>>>>>>..>>.......<<....>>..
.>>>>...>>>>>.>>>...>>>...>>.>...............<<...
<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>.....
.>....................<<.........>>.....<<<<<<<<<<
<<..<<.<<<<<<..<<<.<<<<.......................<<.<
....<<<<<........<.....>......>>>>>......<<<......
..>>>...>.>>.......>>>>.>>>.....<<<<<<<...........
.<<<..<<<<....>>>>..>>>............>>>>>>>........
........>>>>>>....<<<<<<<<.......>>>>>>>>......>>.
..>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.<<
<..<.<<......<<<<<<<...<<.<<<......>>>.>>...>>>>>>
>......>>.>..>>>.>>>>>>>....>>.>>>>...............
.<<<<<<<<<....>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6lqq Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): G461 R462
• Binding residue (residue number reindexed from 1): G2 R3

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0015031 protein transport
• GO:0016192 vesicle-mediated transport

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:6lqq, PDBe:6lqq, PDBj:6lqq
• PDBsum: 6lqq
• PubMed: 32943522
• UniProt: Q06631|BFR2_YEAST Protein BFR2 (Gene Name=BFR2)