Structure of PDB 8scb Chain RR Binding Site BS01

Receptor Information

>8scb Chain RR (length=118) Species: 9986 (Oryctolagus cuniculus)

GRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIA
GYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPD
TKEMLKLLDFGSLSNLQV

Ligand information

>8scb Chain 9 (length=1692)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgccacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccc
cccguggcggcgacgaccauucgaacgucugcccuaucaacuuucgaugg
uagucgccgugccuaccauggugaccacgggugacggggaaucaggguuc
gauuccggagagggagccugagaaacggcuaccacauccaaggaaggcag
caggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaau
aacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuua
aauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgc
gguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagc
ucguaguuggaucuugggagcgggcguccccgccuuuacuuugaaaaaau
uagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaaua
auggaauaggaccgcgguucuauuuugguuuucggaacugaggccaugau
uaagagggacggccgggggcauucguauugcgccgcuagaggugaaauuc
uuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuu
ucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccguc
guaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucc
caugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggg
ggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcacca
ccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacc
cggcccggacacggacaggauugacagauugauagcucuuucucgauucc
gugggugguggugcauggccguucuuaguugguggagcgauuugucuggu
uaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccc
ccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagc
cacccgagauugagcaauaacaggucugugaugcccuuagauguccgggg
cugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccgg
caggcgcggguaacccguugaaccccauucgugauggggaucggggauug
caauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcu
ugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuacc
gauuggaugguuuagugaggcccucggaucggccccgccggggugcccug
gcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaag
ucguaacaagguuuccguaggugaaccugcggaaggaucauu

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<.......<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>
>>....<<<<<...<......>..>>>>>............<<<.<<<<.
.....>>>>>>>...>>>>...>>..>.>>>.<<<....<<<....<<<<
<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>
....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>
>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>...
..<<.<<<<<<.<<<....>>>..>>>>>>..>>......<<..<.....
......>..>>.........<<<<<((......<<<<.....<<..))>>
.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.
<<...<<<.<<.....<<.<.<<....>>.>.>>.<<<<<<.<.......
<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>
>.......<<.<..<<<<<<<............>>>>>>>.>.>>....>
>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>
......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>
>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>
...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<.....
...>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<
<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<
<..<<<<<..<<<.<<<<<<......<<........>>..........<<
<<<.<....<<<..........<<.<<<........>>>.>>........
>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<.
.....>>>...>>.>>>....<<<...<...<<<<..<<<.....<<<..
.<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>
>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>.
..>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<..
..>>>>.>>>....>.........>>>.>>......<...<.<<<<<...
.......>>>>>>....>.....>>>>>.....<<<<<<<<.......>>
>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<
....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>
>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>
.>>...>.....<<<<<<<<<<..>>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8scb Structure and consequences of eRF1 glued to the ribosomal decoding center
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): G2 R3 V4 R5 T6 K7 K10 F28 K32 S43 K44 K45 N48 K49 G52 H56 K59 R60 R67
• Binding residue (residue number reindexed from 1): G1 R2 V3 R4 T5 K6 K9 F27 K31 S42 K43 K44 N47 K48 G51 H55 K58 R59 R66

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8scb, PDBe:8scb, PDBj:8scb
• PDBsum: 8scb
• PubMed: 38172604
• UniProt: G1TU13|RS17_RABIT Small ribosomal subunit protein eS17 (Gene Name=RPS17)