Structure of PDB 6lqp Chain RP Binding Site BS01

Receptor Information
>6lqp Chain RP (length=2109) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFKARIDDLKIEPASHFLASFDQWKEINLSAKFTEFAAEIEHDVQTLPQI
LYHDKKIFNSLVSFINFHDEFSLQPLLDLLAQFCHDLGPDFLKFYEEAIK
TLINLLDAAIEFESSNVFEWGFNCLAYIFKYLSKFLVKKLVLTCDLLIPL
LSHSKEYLSRFSAEALSFLVRKCPVSNLREFVRSVFEKLELYEGLLILFT
ESMTSTQETLHSKAKAIMSVLLHEALTKSSPERSVSLLSDIWMNISKYAS
IESLLPVYEVMYQDFNDSRILKVLTTIVFSEIPDWNKITILIERIMLSQD
KVAFLFALFIRNSDVKTLTLFHQKLFNYALTNISDCFLEFFQFALRLSYE
RVFSFLFLKKNWQSQGKKIALFFLEVDDKPELQKVREVNFPEEFILSIRD
FFVTAEINDSNDLFEIIFKYSKLQNTEIIERIFSTFASPDNFTKGTLLKI
YRKEDDASLKTILDNYENYKESLGWNKLVSNLHPSESLKGLMSHYPSLLL
SLTDNFMLPDGKIRYKTLMILQGMQVPDLLSSCMVIEEIPLTLQNARDLT
IRIKTKTDKLVSSFFLKYLFGLLTVRFSPVWTGVFDTLPNVYTKDEALVW
KLVLSFIKLPDENQNLDYYQPLLEDGANKVLWDSSVVRLRDTIDTFSHIW
SKYSTQNTSIISTTIERRGNTTYPILIRNQALKVMLSIPQVAENHFVDIA
PFVYNDFKTYKDEEDMENERVITGSWTEVDRNVFLKTLSKFKNIKNVYSA
TELHDHLMVLLGSRNTDVQKLALDALLAYKNPTLNKYRDNLKNLLDDTLF
KDEITTFLTENGSQSIKAEDEKVVMPYVLRIFFGRAQVPPTSGQKRSRKI
AVISVLPNFKKPYINDFLSLASERLDYNYFFGNSHQINSSKATLKTIRRM
TGFVNIVNSTLSVLRTNFPLHTNSVLQPLIYSIAMAYYVLDTESTEEVHL
RKMASNLRQQGLKCLSSVFEFVGNTFDWSTSMEDIYAVVVKPRISHFSDE
NLQQPSSLLRLFLYWAHNPSLYQFLYYDEFATATALMDTISNQHVKEAVI
GPIIEAADSIIRNPVNDDHYVDLVTLICTSCLKILPSLYVKLSDSNSIST
FLNLLVSITEMGFIQDDHVRSRLISSLISILKGKLKKLQENDTQKILKIL
KLIVFNYNCSWSDIEELYTTISSLFKTFDERNLRVSLTELFIELGRKVPE
LESISKLVADLNSYSSSRMHEYDFPDFINEKPNLNEASKSISMLKDILLP
NIRIGLRDSLEEVVLSYMVKNTKYFTDFEDMAILLYNGDEEADRRQRAIK
RLGEHAHQLKDNSISHYLIPMIEHYVFSDDERYRNIGNETQIAIGGLAQH
MSWNQYKALLRRYISMLKTKPNQMKQAVQLITLRIVRDGAESKLTLSKFP
SERMPIAEALVNIVLGLTNDDITNFLPSILTNICQVLRSKSEELRDAVRV
TLGKISIILGAEYLVFVIKELMATLKRGSQIHVLSYTVHYILKSMHGVLK
HSDLDTSSSMIVKIIMENIFGFAGEEKDSENYHTKVKEIKSNKSYDAGEI
LASNISLTEFGTLLSPVKALLMVRINLRNQNKLSELLRRYLLGLNHNSDS
ESESILKFCHQLFQESESLLLNSTLQKFALDLLRNVITRHRSFLTVSHLE
GFIPFLRDSLLSENEGVVISTLRILITLIRLDFSDESSEIFKNCARKVLN
IIKVSPSTSSELCQMGLKFLSAFIRHTDSTLKDTALSYVLGRVLPDLNEP
SRQGLAFNFLKALVSKHIMLPELYDIADTTREIMVTNHSKEIRDVSRSVY
YQFLMEYDQSKGRLEKQFKFMVDNLQYPTESGRQSVMELINLIITKPALL
SKLSSSFFLALVNVSFNDDAPRCREMASVLISTMLPKLENKDLEIVEKYI
AADNASFLNLGLRTYKVSIGFEHTIELDELAIKRIRFSSYMEATESVYKH
GWDGIITCLLYPHSWVANLVHQLIANKDKLEISLTTIATRILHQLGAPSI
PANVSIKTLVNISILWKEQTGEDLKYTTAIDYMVTRGIIRSDEHRMDSFM
SKALLVQVLDEDEVIAEGEYLETYYSRAVDEEQEELLEDKLQVSDFTKIY
TAVKQTVLE
Ligand information
>6lqp Chain 5A (length=523) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucg
ucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucu
auacagcguguuuaauugacauggguugaugcguauugagagauacaauu
ugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacaguc
ucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuuggug
gauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaau
gccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuc
cucucaaaucagcgauaucaaacguaccaccgugaaacaccgggguaucu
guuugguggaaccugauuagaggaaacucaaagagugcuaugguauggug
acggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuu
ccggcagcagagauuucagcugu
<<<....>>>...<<<<<<<<<<.>>>>>>>.>>>..............<
<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>
...>>.>>>......>>>>>..<<<<<..........<<<<<<<<<<.<<
<<<<<<....>>>>>>>.>>>>>>>>>>>........>>>>>.......<
<<<<<<<<<<...........>>>>>.>>>>>>.................
........<<<...>>>.........................<<<<<..<
<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>
>.....<<<<<<...<<<<<<<<<<<<<.<<<........>>>>>>>.>.
>>>>>>>>....>>>>>>................................
.<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>
>>><<<<<.<<<..>>>.>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqp Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E1932 K1935 N1936 R1939 K1975
Binding residue
(residue number reindexed from 1)		E1689 K1692 N1693 R1696 K1732
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030686 90S preribosome
GO:0030688 preribosome, small subunit precursor
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lqp, PDBe:6lqp, PDBj:6lqp
PDBsum6lqp
PubMed32943522
UniProtP35194|UTP20_YEAST U3 small nucleolar RNA-associated protein 20 (Gene Name=UTP20)

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