Structure of PDB 7qvp Chain RF Binding Site BS01

Receptor Information
>7qvp Chain RF (length=180) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCP
IVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAII
NSGPREDSTRRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA
DELINAAKGSSNSYAIKKKDELERVAKSNR
Ligand information
>7qvp Chain S3 (length=1705) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuugggggggaugcg
ugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccg
uggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguag
ucgccgugccuaccauggugaccacgggugacggggaaucaggguucgau
uccggagagggagccugagaaacggcuaccacauccaaggaaggcagcag
gcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaca
auacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauc
cuuuaacgaggauccauuggagggcaagucuggugccagcagccgcggua
auuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucgu
aguuggaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgc
ccguccccgccgcguuuacuuugaaaaaauuagaguguucaaagcaggcc
cccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuau
uuuuuuucggaacugaggccaugauuaagagggacggccgggggcauucg
uauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccaga
gcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgga
gguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccg
accggcgaugcggcggcguuauucccaugacccgccgggcagcuuccggg
aaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacu
uaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaau
uugacucaacacgggaaaccucacccggcccggacacggacaggauugac
agauugauagcucuuucucgauuccgugggugguggugcauggccguucu
uaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucu
ggcaugcuaacuaguuacgcgaccccgcggucggcgucaacuucuuagag
ggacaaguggcguucagccacccgagauugagcaauaacaggucugugau
gcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgu
gugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgu
gauggggaucggggauugcaauuauuccccaugaacgaggaauucccagu
aagugcgggucauaagcuugcguugauuaagucccugcccuuuguacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggugcggagcgcugagaagacggucgaacuugacuaucuag
aggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggau
cauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<.........<<.....<<.<<<....
.>>>.>>......>>.........<<<<...<<<<.....>>>>...>>>
><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<..
.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<
.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>...
.>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>
>>.........<<<....<<<<...>>>>..>>>..>...>>.>....<<
.<<<<<<............>>.>>>>..>>......<<..<.........
..>..>>.........<<<<<((......<<<<.....<<..))>>....
...>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<..
.<<<.<<..........<<<<<<<<<<<.<<<<....>>>>>....>>>>
>>>>>>.........<<<<<<.<.......<<...<.......>.<<<<.
...>>>>...>>......>.>>>..>>>........<.<<.<<.<<<<..
........>>>>.>>.>>.>....>>....<<<<<<..<...<<<<..<<
..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......
<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<
<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.
<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<.
.))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>
>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<.....
.<<........>>..........<<<<<......<<<<<<.......<<.
<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<..
..<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<.
..<...<<<<..<<<<<<<<<<<<....>>>>.>>>>.>>>>..>>>>..
>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>
>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........
<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..
..........<<<<<..........>>>>>...........>>>>>....
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<
<...<<......>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>..
.>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H51 A57 A58 K59 R60 K63 R71 N74 H79 R81 N82 N83 G84 K85 K86 L87 M88 N148 R159 F163 R164 N165 I166 T168 I169
Binding residue
(residue number reindexed from 1)		H34 A40 A41 K42 R43 K46 R54 N57 H62 R64 N65 N66 G67 K68 K69 L70 M71 N124 R135 F139 R140 N141 I142 T144 I145
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
PDBsum7qvp
PubMed36302773
UniProtA0A6J0Y1Z7

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