Structure of PDB 6lqr Chain RE Binding Site BS01

Receptor Information
>6lqr Chain RE (length=1079) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNIFKLQIDELLEQVKLKQKHVLKVEKFLHKLYDILQEIPDWEEKSLAEV
DSFFKNKIVSVPFVDPKPIPQNTNYKFNYKKPDISLIGSFALKAGIYQPN
GSSIDTLLTMPKELFEKKDFLNFRCLHKRSVYLAYLTHHLLILLKKDKLD
SFLQLEYSYFDNDPLLPILRISCSKDYNFYKTRFSINLLIGFPYKVFEPK
KLLPNRNCIRILPATPLYNFSVLSSSTHENYLKYLYKTKKQTESFVEATV
LGRLWLQQRGFSSNMSHSGSLGGFGTFEFTILMAALLNGGGINSNKILLH
GFSSYQLFKGVIKYLATMDLCHDGHLQFHSNPASKYIDEGFQTPTLFDKS
TKVNILTKMTVSSYQILKEYAGETLRMLNNVVQDQFSNIFLTNISRFDNL
KYDLCYDVQLPLGKYNNLETSLAATFGSMERVKFITLENFLAHKITNVAR
YALGDRIKYIQIEMVGQKSDFPITKRKVYSNTGGNHFNFDFVRVKLIVNP
SECDKLVTKGPAHSETMSTEAAVFKNFWGIKSSLRRFKDGSITHCCVWST
SSSEPIISSIVNFALQKHVSKKAQISNETIKKFHNFLPLPNLPSSAKTSV
LNLSSFFNLKKSFDDLYKIIFQMKLPLSVKSILPVGSAFRYTSLCQPVPF
AYSDPDFFQDVILEFETSPKWPDEITSLEKAKTAFLLKIQEELSANSSTY
RSFFSRDESIPYNLEIVTLNILTPEGYGFKFRVLTERDEILYLRAIANAR
NELKPELEATFLKFTAKYLASVRHTRTLENISHSYQFYSPVVRLFKRWLD
THLLLGHITDELAELIAIKPFVDPAPYFIPGSLENGFLKVLKFISQWNWK
DDPLILDLVKPEERLTLAQYKGIQMNFTNLRNSDPNGTHLQFFVASKNDP
SGILYSSGIPLPIATRLTALAKVAVNLLQTHGLNQQTINLLFTPGLKDYD
FVVDLRTPIGLKSSCGILSAPSNFPENLNDLSEKMDPTYQLVKYLNLKYK
NSLILSSRKYIGVNGGEKGDKNVITGLIKPLFKGAHKFRVNLDCNVKPVD
DENVILNKEAIFHEIAAFGNDMVINFETD
Ligand information
>6lqr Chain SA (length=1283) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagauaguuaucugguugauccugccaguagucauaugcuugucucagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucau
uaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauu
cuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauu
agaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcaugg
ccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgau
gguaggauaguggccuaccaugguuucaacggguaacggggaauaagggu
ucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggc
agcaggccaaauuacccaauccuaauucagggagguagugacaauaaaua
acgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaa
uaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguagu
ugaacuggcccgguuggccgguccggauuuccaacggggccuugguucua
uuuucuaggacugauuaauagggacggucgggggcaucaguauucaauug
ucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcau
uugccaaggacguuuucauuaaucaagaacgccgacuagggaucgggugg
uguuuuuuuaaugacccacucggcaccuuacgagacuggggggaguaugg
ucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggagug
gagccugcggcucaacacggggaaacucaccagguccagacacaauaagg
auugacauucuugauuuugugggugguggugcauugaugcccuuguucug
ggccacgcgcgcuacacugacggagccagcgagucuagugaaacuccguc
gugcuggcaacgaggaauuccuaguaagcgcaagucaucagcuugcguug
auuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaa
uggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucu
cagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagugg
uuuccguaggugaaccugcggaaggaucauuaa
............................<<<<.<<<<<<........<<<
.<<...<<....<<....<<..........>>...>>.>>.....<<<..
.....<<<..<<..<<....<<<..........<.....<<.<<......
.>>.>>......>.......<<<<............>>>>.....<<<<<
...<<<<..............>>>>...>>>>>.........<<<<...<
<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<
<<<<<<.......>>>>>>>>>>>......>>>.....<<..........
.....>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>..
..>>>>>......<<<....<<<.....>>>..>>>..............
.<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<.......
....>..>>.........<<<<<<.......<<<....>>>.........
.........>>>>>>..>>>>>>>>>>.........<....<.<<...<<
<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>.<..<<..<
...>..>>.>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<
...<<<......>>>......>.>>>>>>..>>.......<<....>>..
.>>>>...>>>>>.>>>...>>>...>>.>..<<...<<<..<<<<<<<<
.<<<........>>>>>>>>>>>..>>>..>>.....>............
........<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<.
.<<<.<<<<.......................<<.<....<<<<<.....
...<.....>......>>>>>......<<<........>>>...>.>>..
.....>>>>.>>>.....<<<<<<<..................>>>>>>>
................>>>>>>....<<<<<<<<.......>>>>>>>>.
.....>>...>>>>>>>............>>>>>..<<<<.<<.....<<
<<<<<.<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>.
..>>>>>>>......>>.>..>>>.>>>>>>>....>>.>>>>.......
.<<<<<<<<<....>>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqr Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution8.6 Å
Binding residue
(original residue number in PDB)		N171 N173 K175 E215 K217 K306 P790 K791 W792 R858 R865
Binding residue
(residue number reindexed from 1)		N72 N74 K76 E116 K118 K200 P669 K670 W671 R737 R744
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006364 rRNA processing
GO:0006409 tRNA export from nucleus
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
GO:0060962 regulation of ribosomal protein gene transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0032545 CURI complex
GO:0034456 UTP-C complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lqr, PDBe:6lqr, PDBj:6lqr
PDBsum6lqr
PubMed32943522
UniProtP53254|UTP22_YEAST U3 small nucleolar RNA-associated protein 22 (Gene Name=UTP22)

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