Structure of PDB 6ke6 Chain RE Binding Site BS01

Receptor Information
>6ke6 Chain RE (length=1079) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNIFKLQIDELLEQVKLKQKHVLKVEKFLHKLYDILQEIPDWEEKSLAEV
DSFFKNKIVSVPFVDPKPIPQNTNYKFNYKKPDISLIGSFALKAGIYQPN
GSSIDTLLTMPKELFEKKDFLNFRCLHKRSVYLAYLTHHLLILLKKDKLD
SFLQLEYSYFDNDPLLPILRISCSKDYNFYKTRFSINLLIGFPYKVFEPK
KLLPNRNCIRILPATPLYNFSVLSSSTHENYLKYLYKTKKQTESFVEATV
LGRLWLQQRGFSSNMSHSGSLGGFGTFEFTILMAALLNGGGINSNKILLH
GFSSYQLFKGVIKYLATMDLCHDGHLQFHSNPASKYIDEGFQTPTLFDKS
TKVNILTKMTVSSYQILKEYAGETLRMLNNVVQDQFSNIFLTNISRFDNL
KYDLCYDVQLPLGKYNNLETSLAATFGSMERVKFITLENFLAHKITNVAR
YALGDRIKYIQIEMVGQKSDFPITKRKVYSNTGGNHFNFDFVRVKLIVNP
SECDKLVTKGPAHSETMSTEAAVFKNFWGIKSSLRRFKDGSITHCCVWST
SSSEPIISSIVNFALQKHVSKKAQISNETIKKFHNFLPLPNLPSSAKTSV
LNLSSFFNLKKSFDDLYKIIFQMKLPLSVKSILPVGSAFRYTSLCQPVPF
AYSDPDFFQDVILEFETSPKWPDEITSLEKAKTAFLLKIQEELSANSSTY
RSFFSRDESIPYNLEIVTLNILTPEGYGFKFRVLTERDEILYLRAIANAR
NELKPELEATFLKFTAKYLASVRHTRTLENISHSYQFYSPVVRLFKRWLD
THLLLGHITDELAELIAIKPFVDPAPYFIPGSLENGFLKVLKFISQWNWK
DDPLILDLVKPEERLTLAQYKGIQMNFTNLRNSDPNGTHLQFFVASKNDP
SGILYSSGIPLPIATRLTALAKVAVNLLQTHGLNQQTINLLFTPGLKDYD
FVVDLRTPIGLKSSCGILSAPSNFPENLNDLSEKMDPTYQLVKYLNLKYK
NSLILSSRKYIGVNGGEKGDKNVITGLIKPLFKGAHKFRVNLDCNVKPVD
DENVILNKEAIFHEIAAFGNDMVINFETD
Ligand information
>6ke6 Chain SA (length=1310) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agauaguuaucugguugauccugccaguagucauaugcuugucucagcca
ugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauu
aaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauuc
uagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauua
gaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggc
cuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaug
guaggauaguggccuaccaugguuucaacggguaacggggaauaaggguu
cgauuccggagagggagccugagaaacggcuaccacauccaaggaaggca
gcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaa
cgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaau
accuuaacgaggaacaauuggagggcaagucuggugccagcagccgcggu
aauuccagcuccaauagcguauauuaaaguuguugcagaagcucguaguu
gaacuggcccgguuggccgguccggauuuccaacggggccuugauuaaua
gggacggucgggggcaucaguauucaauugucagaggugaaauucuugga
uuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauu
aaucaagaacgaccauaaacuaugccgacuagggaucgggugguguuuuu
uuaaugacccacucggcaccuuacgagaacuggggggaguauggucgcaa
ggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccu
gcggcucaacacggggaaacucaccagguccagacacaauaaggauugac
auucuugauuuugugggugguggugcauugaugcccuuguucugggccac
gcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuu
gguaaucuugugaaacuccgucgugcuggggauauucaacgaggaauucc
uaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuugua
cacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucagga
ucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaa
acuuggucauuuagaggaacuaaaagucguaacaagguuuccguagguga
accugcggaa
...........................<<<<.<<<<<<...<....<<<.
<<...<<....<<....<<..........>>...>>.>>.....<<<...
....<<<..<<..<<....<<<..........<....<<<.<<<.....>
>>.>>.>....>.......<<<<............>>>>.....<<<<<.
..<<<<.<........>...>>>>...>>>>>.........<<<<..<<<
.....>>>.>>>>....>>>...>>>>..>>>.<.<....<<<....<<<
<<<<<.......>>>>>>>>>>>......>.>.....<<...........
....>>..>>>.<<.<<<..........>>>.>>...<<....>>.....
.>>>>>......<<<....<<<.....>>>..>>>.........>.....
<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<........
...>..>>.........<<<<<<.......<<<....>>>..........
........>>>>>>..>>>>>>>>>>..............<.<<...<<<
.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>....>>....
<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>.....
.>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...
>>>...>>.>...............<<...<<<..<<<<<<<<.<<<...
.....>>>>>>>>>>>..>>>..>>.........................
..<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<
<<<.......................<<......<<<<<...........
..........>>>>>......<<<........>>>.....>>.......>
>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..
>>>............>>>>>>>.......................>>>>>
>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>....
........>>>>>..<<<<.<<.....<<<<<<<.<<<..<.<<......
<<<<<<<...<<.<<<<....>>>>.>>...>>>>>>>......>>.>..
>>>.>>>>>>>....>>.>>>>................<<<<<<<<<...
.>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ke6 3.4 angstrom cryo-EM structure of yeast 90S small subunit preribosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		N171 N173 K306 K307 C314 P790 W792 D794 R858 R865
Binding residue
(residue number reindexed from 1)		N72 N74 K200 K201 C208 P669 W671 D673 R737 R744
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006364 rRNA processing
GO:0006409 tRNA export from nucleus
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
GO:0060962 regulation of ribosomal protein gene transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0032545 CURI complex
GO:0034456 UTP-C complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ke6, PDBe:6ke6, PDBj:6ke6
PDBsum6ke6
PubMed
UniProtP53254|UTP22_YEAST U3 small nucleolar RNA-associated protein 22 (Gene Name=UTP22)

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