Structure of PDB 7a01 Chain R2 Binding Site BS01

Receptor Information
>7a01 Chain R2 (length=35) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYAAP
Ligand information
>7a01 Chain e2 (length=3825) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgccccccguggggucggcgggggaccguccccc
gaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggc
ccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccg
agggagcgagacccgucgccgcgcucuccccccucggcgucuccucgugg
gggggccgggccaccccucccacggcgcgaccgcucucccaccccucguc
ggggggcggggcggacuguccccagugcgccccgggcgggucgcgccguc
gggcccgggggagguucucucggggccacgcgcgcgucccccgaagaggg
ggacggcggagcgagcgcacggggucggcggcgacgucggcuacccaccc
gacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucggg
ggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcu
cgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcac
caccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacg
uguuaggacccgaaagauggugaacuaugccugggcagggcgaagccaga
ggaaacucugguggagguccguagcgguccugacgugcaaaucggucguc
cgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguu
cccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgca
cccccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggg
gccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccg
gcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuu
ugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcg
cccgaugccgacgcucaucagaccccagaaaagguguugguugauauaga
cagcaggacgguggccauggaagucggaauccgcuaaggaguguguaaca
acucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcguc
gggcccauacccggccgucgccggcagucgagaguggacgggagcggcgg
gggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccg
cgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggc
ccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauuc
aaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagca
guugaacaugggucagucgguccugagagaugggcgagcgccguuccgaa
gggacgggcgauggccuccguugcccucggccgaucgaaagggagucggg
uucagauccccgaauccggaguggcggagaugggcgccgcgaggcgucca
gugcgguaacgcgaccgaucccggagaagccggcgggagccccggggaga
guucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccg
agagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggu
gagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcg
ccgggccguacccauauccgcagcaggucuccaaggugaacagccucugg
cauguuggaacaauguagguaagggaagucggcaagccggauccguaacu
ucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcg
gaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccg
cggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaa
gugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacuc
ucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaug
gaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagc
caagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagc
uugacucuagucuggcacggugaagagacaugagagguguagaauaagug
ggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggg
uccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuu
uucacugacccggugaggcgggggggcgagccccgaggggcucucgcuuc
uggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccgggg
acagugccagguggggaguuugacuggggcgguacaccugucaaacggua
acgcagguguccuaaggcgagcucagggaggacagaaaccucccguggag
cagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagacc
gugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcagga
ggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgu
ucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauu
gugaagcagaauucaccaagcguuggauuguucacccacuaauagggaac
gugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugau
gauguguuguugccaugguaauccugcucaguacgagaggaaccgcaggu
ucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcua
ccaucugugggauuaugacugaacgccucuaagucagaaucccgcccagg
cggaacgauacggcagcgccgcggagccucgguuggccucggauagccgg
ucccccgccgggaccgggguccggugcggagugcccuucguccugggaaa
cggggcgcggccggagaggcggccgcccccucgcccgucacgcaccggcc
guucguggggaaccuggcgcuaaaccauucguagacgaccugcuucuggg
ucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaa
gucagcccucgacacaaggguuugu
.........................<<<<<<.....<......>......
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>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>...<<<<<<<<<....<<<<<<<<........<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>....................................<<<<<...<<<..
....<<<<<<<<.<<<.....<<<<<<<<<<<...<<<.<<.<<<<<.<<
...<<<<<.<<..<<<<<<<<<<<..>>>>..>>>>>>>>>>>>>>>>>>
>>>>>....>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<
<<<.<<<<<<<<<..<<<....<.....<<<<.<<.<...<...<<<<<.
>>>>>...>.....>>>.>>>>..........>.>>>....>>>>>>>>>
....................<<<<<..<<<<<<................>
>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<........<<<<....
.>>>>..<<<<<<.<<<<....>>>>.>>>>>>..>>.>>>>>>>>>>>.
>>>...>.>>>...........>>.>...........<<.<........>
>>...........>>>>>......>>>.>>>>>....>>>....>>>>>.
...<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...
<<<<........>>>>.....>>>...<<....>>...<<<<<<<.....
.>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>
>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<
<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
<<<<<<....<.<<<....>>>(><<.<<<<<<<................
..............<<<<<<<<....<<<....<<<..<.<<<..<.<..
............>.>.>>>.>..>>>..>.>>....>>>>>>...<<<<<
<<<<........>>>>>>>>>...>>...>>>>>>>..>>).<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(
((.......<<<<<......<..........<<<.<<<<<<<<<<.....
..<<<...<<<...................>>>.........<<......
>>.....>>>...>>>>>>>>>>>>>..........))).>....>>>>>
..>>>...>>>>>>><<<<<<.<<<..........]]..)))........
..............................................>>>>
>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>
>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<
<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<...
..>>.>>>>>>....((<<<<<<...<<....<<<....>>>........
..<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<
........>>>>>))<<<<....<<<<....<<<<<<......>>>>>>.
..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<
<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.
....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.
..>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.
>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>
>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<
..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.
....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....
.<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>
>.........<...........<<<<<.......>>>>>.....>.....
>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[
[..<<<<<.<<<<<<<<<.<<<<<<<<<<.....<..............<
.........<<<<<<<<.<<<<...<.<........>>..>>>.>..>>>
..>>>>>........................>......>......>>>>>
>>>>>...<<<<<.....<<<<...<.<<<<<<....>>>>>>>......
.........<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>.
...>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<.........
..>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<
<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<
<<....>>>.>>)))]......((((((..(((..>>>>>>.))))))))
)..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<..
.....>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.
<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..
>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]
.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.
><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>
...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>..
.>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<
..<<.<<.......>.>>>.>>>>>........>>....<<..<<<<...
.<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>.........
.......>>>..>>>>>>>>><<<<<....................<<.<
<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>
>....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
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PDB7a01 The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
P38 H39 C40 S41 R42 N43 R48 G49 S54 R55 S56 Y59 S60 R61 K62 Y65 K66 R67 Y69 P72
Binding residue
(residue number reindexed from 1)
P1 H2 C3 S4 R5 N6 R11 G12 S17 R18 S19 Y22 S23 R24 K25 Y28 K29 R30 Y32 P35
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7a01, PDBe:7a01, PDBj:7a01
PDBsum7a01
PubMed33296660
UniProtG1U1N5

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