Structure of PDB 8xvh Chain R Binding Site BS01

Receptor Information
>8xvh Chain R (length=305) Species: 1502,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGP
NILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVG
ITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPE
AIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPL
AITAFFYTLMTCEMLRLNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRI
LKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFK
NCFKS
Ligand information
>8xvh Chain T (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CSCSSLMDKECVYFCHLDIIW
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8xvh Structural basis of antagonist selectivity in endothelin receptors.
Resolution3.26 Å
Binding residue
(original residue number in PDB)		P87 N158 K161 E165 W167 Q181 M245 D246 Y247 K248 I254 L256 L257 P259 R343 R357 L361 L365 D368
Binding residue
(residue number reindexed from 1)		P1 N72 K75 E79 W81 Q95 M159 D160 Y161 K162 I168 L170 L171 P173 R249 R263 L267 L271 D274
External links
PDB RCSB:8xvh, PDBe:8xvh, PDBj:8xvh
PDBsum8xvh
PubMed39075075
UniProtP24530|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB);
Q59310

[Back to BioLiP]