Structure of PDB 8xve Chain R Binding Site BS01

Receptor Information
>8xve Chain R (length=308) Species: 1502,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNG
PNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASV
GITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVP
EAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLP
LAITAFFYTLMTCEMLRKKLNDHLKQRREVAKTVFCLVLVFALCWLPLHL
SRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSK
RFKNCFKS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8xve Structural basis of antagonist selectivity in endothelin receptors.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N158 K161 E165 Q181 K182 Y247 I254 P259 K273 L339 R343 K346 Y350 L361 L365 D368 Y369
Binding residue
(residue number reindexed from 1)		N73 K76 E80 Q96 K97 Y162 I169 P174 K188 L248 R252 K255 Y259 L270 L274 D277 Y278
External links
PDB RCSB:8xve, PDBe:8xve, PDBj:8xve
PDBsum8xve
PubMed39075075
UniProtP24530|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB);
Q59310

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