Structure of PDB 8wz2 Chain R Binding Site BS01

Receptor Information

>8wz2 Chain R (length=322) Species: 9606 (Homo sapiens)

EQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFAL
ALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNIS
DNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYT
NRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSP
VHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKMSKIARKKKRAVIM
MVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSN
SICNPIVYAFMNENFKKNVLSA

Ligand information

>8wz2 Chain L (length=25) Species: 9606 (Homo sapiens)

SGPLGTLAEELSSYSRRKGGFSFRF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8wz2 Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
• Resolution: 2.73 Å
• Binding residue (original residue number in PDB): E9 V35 C98 V101 L104 Q105 S108 N110 W111 C118 P122 Q125 C200 C201 L202 E203 Y214 F289 H293 Q318 F322
• Binding residue (residue number reindexed from 1): E1 V27 C90 V93 L96 Q97 S100 N102 W103 C110 P114 Q117 C192 C193 L194 E195 Y206 F265 H269 Q294 F298

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0005515 protein binding
• GO:0042277 peptide binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007218 neuropeptide signaling pathway
• GO:0032870 cellular response to hormone stimulus

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8wz2, PDBe:8wz2, PDBj:8wz2
• PDBsum: 8wz2
• PubMed: 38830850
• UniProt: Q96P65|QRFPR_HUMAN Pyroglutamylated RF-amide peptide receptor (Gene Name=QRFPR)