Structure of PDB 8ww2 Chain R Binding Site BS01

Receptor Information
>8ww2 Chain R (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVAD
LLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYL
SLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGV
VYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHTRKG
IATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPI
IYAFRNQDVQKVLWAVCC
Ligand information
Ligand IDOLA
InChIInChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
InChIKeyZQPPMHVWECSIRJ-KTKRTIGZSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)CCCCCCC\C=C/CCCCCCCC
CACTVS 3.341CCCCCCCCC=CCCCCCCCC(O)=O
CACTVS 3.341CCCCCCCC\C=C/CCCCCCCC(O)=O
OpenEye OEToolkits 1.5.0CCCCCCCCC=CCCCCCCCC(=O)O
OpenEye OEToolkits 1.5.0CCCCCCCC\C=C/CCCCCCCC(=O)O
FormulaC18 H34 O2
NameOLEIC ACID
ChEMBLCHEMBL8659
DrugBank
ZINCZINC000006845860
PDB chain8ww2 Chain R Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ww2 Identification of oleic acid as an endogenous ligand of GPR3.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		H96 L116
Binding residue
(residue number reindexed from 1)		H60 L80
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0019222 regulation of metabolic process
GO:0040020 regulation of meiotic nuclear division
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ww2, PDBe:8ww2, PDBj:8ww2
PDBsum8ww2
PubMed38287117
UniProtP46089|GPR3_HUMAN G-protein coupled receptor 3 (Gene Name=GPR3)

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